Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus
文献类型：期刊论文
| 作者 | Yuan, DD; Liu, L; Shao, XX; Peng, C; Chi, CW; Guo, ZY |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2008 |
| 卷号 | 29期号:9页码:1521-1525 |
| 关键词 | conotoxin cysteine framework signal peptide |
| 通讯作者 | Chi, CW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,zwqi@sibs.ac.cn ; zhan-yun.guo@mail.tongji.edu.cn |
| 英文摘要 | A new conotoxin, ca16a, containing 8 cysteine residues was purified, sequenced, and cloned from a worm-hunting snail, Conus caracteristicus. This conotoxin is an extremely hydrophilic peptide comprising 34 residues, with 4 acidic and 4 basic residues. it is rich in polar Gly, Ser, and Thr residues and includes a hydroxylated Pro residue. The cysteine arrangement pattern of ca16a (-C-C-CC-C-CC-C-, designated as framework #16) is distinct from that of other known conotoxins. Furthermore, the signal peptide sequence of this conotoxin does not share any homology with those of other conotoxins. Leu residues account for almost 50% of its 20-residue signal peptide. The unique cysteine framework and signal peptide sequence of ca16a suggest that it belongs to a new conotoxin superfamily. (C) 2008 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
| 类目[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 关键词[WOS] | SUPERFAMILY CONOTOXINS ; CHANNEL ; IDENTIFICATION ; PEPTIDES ; SEQUENCE ; UNIQUE ; LITTERATUS ; DIVERSITY ; DEFINES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259346400008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1432]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yuan, DD,Liu, L,Shao, XX,et al. Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus[J]. PEPTIDES,2008,29(9):1521-1525. |
| APA | Yuan, DD,Liu, L,Shao, XX,Peng, C,Chi, CW,&Guo, ZY.(2008).Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus.PEPTIDES,29(9),1521-1525. |
| MLA | Yuan, DD,et al."Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus".PEPTIDES 29.9(2008):1521-1525. |
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