The JNK/AP1/ATF2 pathway is involved in H2O2-induced acetylcholinesterase expression during apoptosis
文献类型：期刊论文
| 作者 | Zhang, JY; Jiang, H; Gao, W; Wu, J; Peng, K; Shi, YF; Zhang, XJ |
| 刊名 | CELLULAR AND MOLECULAR LIFE SCIENCES
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| 出版日期 | 2008 |
| 卷号 | 65期号:9页码:1435-1445 |
| 关键词 | JNK/AP1/ATF2 acetylcholinesterase expression apoptosis free radicals |
| 通讯作者 | Zhang, XJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab,Grad Sch Chinese Acad Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xjzhang@sibs.ac.cn |
| 英文摘要 | We show that H2O2 increases acetylcholinesterase (ACNE) expression via transcriptional activation through c-Jun N-terminal kinase (JNK), since the JNK inhibitor SP600125, but not the extracellular signal-regulated kinase (ERK) pathway inhibitor PD98059 or p38 kinase inhibitor 813203580, attenuated H2O2-induced ACNE expression and its promoter activity. Overexpression of hemagglutinin (HA)-JNK increases H2O2-induced ACNE expression and its promoter activity, whereas the dominant negative mutant form of JNK suppressed H2O2-induced ACNE expression and promoter activity. Mutation analysis indicates that the major response elements for JNK in the ACNE promoter are the API-like element (TGAGTCT) site, located within the -1565/-1569 region of the ACNE promoter, and the ATF2 element (CCACGTCA), within the -2185/-2177 region. The AP1-like element binds to the transcription factors, c-jun and ATF2, while the ATF2 element binds mainly ATF2. Taken together, our results strongly suggest that H2O2 induces ACNE expression via the JNK/AP1/ATF2 signaling pathway. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | N-TERMINAL KINASE ; OXIDATIVE STRESS ; NEUROBLASTOMA-CELLS ; ALZHEIMERS-DISEASE ; HYDROGEN-PEROXIDE ; CASPASE-3 ACTIVATION ; SIGNALING PATHWAY ; REACTIVE OXYGEN ; PROMOTER ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000256099200011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1437]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, JY,Jiang, H,Gao, W,et al. The JNK/AP1/ATF2 pathway is involved in H2O2-induced acetylcholinesterase expression during apoptosis[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2008,65(9):1435-1445. |
| APA | Zhang, JY.,Jiang, H.,Gao, W.,Wu, J.,Peng, K.,...&Zhang, XJ.(2008).The JNK/AP1/ATF2 pathway is involved in H2O2-induced acetylcholinesterase expression during apoptosis.CELLULAR AND MOLECULAR LIFE SCIENCES,65(9),1435-1445. |
| MLA | Zhang, JY,et al."The JNK/AP1/ATF2 pathway is involved in H2O2-induced acetylcholinesterase expression during apoptosis".CELLULAR AND MOLECULAR LIFE SCIENCES 65.9(2008):1435-1445. |
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