Acetylcholinesterase in intestinal cell differentiation involves G2/M cell cycle arrest
文献类型：期刊论文
| 作者 | Xiang, AC; Xie, J; Zhang, XJ |
| 刊名 | CELLULAR AND MOLECULAR LIFE SCIENCES
 |
| 出版日期 | 2008 |
| 卷号 | 65期号:11页码:1768-1779 |
| 关键词 | differentiation acetylcholinesterase cell cycle butyrate sodium G2/M |
| 通讯作者 | Zhang, XJ (reprint author), Chinese Acad Sci, Grad Sch, Mol Cell Biol Lab, Inst Biochem & Cell Biol,Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xjzhang@sibs.ac.cn |
| 英文摘要 | Here we examine differentiation of the intestinal cell line Caco-2 following exposure to sodium butyrate (NaBT), using alkaline phosphatase (ALP) activity and carcinoembryonic antigen (CEA) levels as markers of differentiation. We show that acetylcholinesterase (AChE) activity and RNA levels increase during differentiation. Treatment with AChE inhibitors or knockdown of AChE levels by shRNA markedly decrease ALP and CEA levels in a concentration- and time-dependent manner. Finally, our observations suggest that NaBT-induced differentiation of intestinal cells involves AChE-induced cell cycle arrest. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | COLON-CANCER CELLS ; TRAIL-MEDIATED APOPTOSIS ; PERIPHERAL ANIONIC SITE ; SODIUM-BUTYRATE ; EPITHELIAL-CELLS ; CACO-2 CELLS ; IN-VITRO ; ALKALINE-PHOSPHATASE ; ADENOCARCINOMA CELLS ; COLLAGEN-IV |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000256471200012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1456]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xiang, AC,Xie, J,Zhang, XJ. Acetylcholinesterase in intestinal cell differentiation involves G2/M cell cycle arrest[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2008,65(11):1768-1779. |
| APA | Xiang, AC,Xie, J,&Zhang, XJ.(2008).Acetylcholinesterase in intestinal cell differentiation involves G2/M cell cycle arrest.CELLULAR AND MOLECULAR LIFE SCIENCES,65(11),1768-1779. |
| MLA | Xiang, AC,et al."Acetylcholinesterase in intestinal cell differentiation involves G2/M cell cycle arrest".CELLULAR AND MOLECULAR LIFE SCIENCES 65.11(2008):1768-1779. |
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