Adenovirus-mediated HCCS1 overexpression elicits a potent antitumor efficacy on human colorectal cancer and hepatoma cells both in vitro and in vivo
文献类型：期刊论文
| 作者 | Gan, Y; Gu, J; Cai, X; Hu, J; Liu, XY; Zhao, X |
| 刊名 | CANCER GENE THERAPY
 |
| 出版日期 | 2008 |
| 卷号 | 15期号:12页码:808-816 |
| 关键词 | hepatocellular carcinoma suppressor 1 gene therapy oncolytic adenovirus |
| 通讯作者 | Zhao, X (reprint author), Shanghai Canc Inst, Lab Cellular & Mol Immunol, Ln2200-25 Xie Tu Rd, Shanghai 200032, Peoples R China.,xyliu@sibs.ac.cn ; xtzhao@sci.shmu.edu.cnor |
| 英文摘要 | We had characterized earlier the novel tumor suppressor gene hepatocellular carcinoma suppressor 1 (HCCS1), and demonstrated that expression of exogenous HCCS1 gene in human hepatocarcinoma cells could remarkably suppress their abilities to develop tumors in nude mice and to form colonies in soft agar. In this study, we provide further experimental evidence to confirm the role of HCCS1 as a tumor suppressor gene and investigate its potential in therapeutic applications by using adenovirus vectors. We show that HCCS1 overexpression, mediated by replication-deficient adenovirus, significantly suppressed the growth of human colorectal cancer cells, as well as hepatocellular carcinoma cells in vitro and in vivo. To further improve its antitumor efficacy, we inserted the HCCS1 gene into an oncolytic adenovirus. This HCCS1-armed oncolytic adenovirus exhibited a dramatic inhibitory effect on cancer cells in vitro and in vivo, and led to a complete regression of 50% of established tumor xenografts in nude mice. Taken together, our data suggest that HCCS1 is a promising therapeutic gene for the treatment of human cancers. |
| 学科主题 | Biotechnology & Applied Microbiology; Oncology; Genetics & Heredity; Research & Experimental Medicine |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Oncology ; Genetics & Heredity ; Medicine, Research & Experimental |
| 关键词[WOS] | HUMAN HEPATOCELLULAR-CARCINOMA ; GENE-VIROTHERAPY ; CHROMOSOME 17P13.3 ; APOPTOSIS ; THERAPY ; GROWTH ; VECTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260832700005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1459]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Gan, Y,Gu, J,Cai, X,et al. Adenovirus-mediated HCCS1 overexpression elicits a potent antitumor efficacy on human colorectal cancer and hepatoma cells both in vitro and in vivo[J]. CANCER GENE THERAPY,2008,15(12):808-816. |
| APA | Gan, Y,Gu, J,Cai, X,Hu, J,Liu, XY,&Zhao, X.(2008).Adenovirus-mediated HCCS1 overexpression elicits a potent antitumor efficacy on human colorectal cancer and hepatoma cells both in vitro and in vivo.CANCER GENE THERAPY,15(12),808-816. |
| MLA | Gan, Y,et al."Adenovirus-mediated HCCS1 overexpression elicits a potent antitumor efficacy on human colorectal cancer and hepatoma cells both in vitro and in vivo".CANCER GENE THERAPY 15.12(2008):808-816. |
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