A novel strategy for cancer treatment: Targeting cancer stem cells
文献类型：期刊论文
| 作者 | Liu, J; Ma, LN; Wang, YG; Liu, XY; Qian, QJ |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2008 |
| 卷号 | 53期号:12页码:1777-1783 |
| 关键词 | cancer stem cell targeting oncolytic adenovirus strategy |
| 通讯作者 | Qian, QJ (reprint author), Zhejiang Sci Tech Univ, Xin Yuan Inst Med & Biotechnol, Coll Life Sci, Hangzhou 310018, Peoples R China.,qianqj@163.sino-gene.cn |
| 英文摘要 | Cancer stem cell/tumor-initiating cell (CSC/TIC) is a subclass of cancer cells possessing parts of properties of normal stem cell. It has a high capacity of proliferation and plays a pivotal role in tumor recurrence and tumor resistance to radiotherapy and chemotherapy. At present, small molecule inhibitors and fusion proteins are widely used in the CSC-targeting strategy. Gene-virotherapy, which uses oncolytic adenovirus as a vector to mediate the expression of therapeutic gene, shows a significant superiority to other regimens of cancer treatment and has a good efficacy in the treatment of solid tumors. Thus, it is a promising choice to apply gene-virotherapy into the CSC-targeting treatment. Based on the molecular mechanism underlying CSC self-renewal, a series of effective strategies for targeting CSC have been established. This review will summarize the recent research progresses on CSC-targeting treatment. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | ACUTE MYELOID-LEUKEMIA ; TUMOR-INITIATING CELLS ; TRANS-RETINOIC ACID ; GENE-THERAPY ; PROSPECTIVE IDENTIFICATION ; ANTITUMORAL EFFICACY ; LENTIVIRAL VECTORS ; PANCREATIC-CANCER ; SIDE POPULATION ; BRAIN-TUMORS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000256963000001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1463]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, J,Ma, LN,Wang, YG,et al. A novel strategy for cancer treatment: Targeting cancer stem cells[J]. CHINESE SCIENCE BULLETIN,2008,53(12):1777-1783. |
| APA | Liu, J,Ma, LN,Wang, YG,Liu, XY,&Qian, QJ.(2008).A novel strategy for cancer treatment: Targeting cancer stem cells.CHINESE SCIENCE BULLETIN,53(12),1777-1783. |
| MLA | Liu, J,et al."A novel strategy for cancer treatment: Targeting cancer stem cells".CHINESE SCIENCE BULLETIN 53.12(2008):1777-1783. |
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