Arginine methylation of hnRNP K enhances p53 transcriptional activity
文献类型：期刊论文
| 作者 | Chen, YB; Zhou, XY; Liu, N; Wang, CC; Zhang, L; Mo, W; Hu, G |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2008 |
| 卷号 | 582期号:12页码:1761-1765 |
| 关键词 | hnRNP K UV radiation arginine methylation p53 transcriptional regulation |
| 通讯作者 | Hu, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,hgxgene@sunm.shcnc.ac.cn |
| 英文摘要 | Previous studies have illustrated that hnRNP K, which could be methylated at arginine residues, plays a key role in coordinating transcriptional responses to DNA damage as a cofactor for p53. In this study, we observed that hnRNP K was markedly arginine methylated in response to UV radiation. Furthermore, arginine methylation of hnRNP K enhanced its affinity with p53. Inhibition of methylation in hnRNP K attenuated the recruitment of p53 to p21 promoter, and reduced p53 transcriptional activity. These data suggested that arginine methylation of hnRNP K is a key element for p53 transcriptional activity. (C) 2008 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | NUCLEAR-RIBONUCLEOPROTEIN-K ; DNA-DAMAGE ; TUMOR-SUPPRESSOR ; ACTIVATES P53 ; C-SRC ; PROTEIN ; COACTIVATOR ; PHOSPHORYLATION ; PATHWAYS ; TARGET |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000258110600022 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1464]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chen, YB,Zhou, XY,Liu, N,et al. Arginine methylation of hnRNP K enhances p53 transcriptional activity[J]. FEBS LETTERS,2008,582(12):1761-1765. |
| APA | Chen, YB.,Zhou, XY.,Liu, N.,Wang, CC.,Zhang, L.,...&Hu, G.(2008).Arginine methylation of hnRNP K enhances p53 transcriptional activity.FEBS LETTERS,582(12),1761-1765. |
| MLA | Chen, YB,et al."Arginine methylation of hnRNP K enhances p53 transcriptional activity".FEBS LETTERS 582.12(2008):1761-1765. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。