Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons
文献类型：期刊论文
| 作者 | Xu, Y; Lopes, C; Qian, Y; Liu, Y; Cheng, LP; Goulding, M; Turner, EE; Lima, D; Ma, QF |
| 刊名 | JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2008 |
| 卷号 | 28期号:15页码:4037-4046 |
| 关键词 | dorsal spinal cord peptidergic neurons Tlx3 cell fate specification transcriptional regulation pain |
| 通讯作者 | Ma, QF (reprint author), Dana Farber Canc Inst, 1 Jimmy Fund Way, Boston, MA 02115 USA.,Qiufu_Ma@dfci.harvard.edu |
| 英文摘要 | The dorsal spinal cord synthesizes a variety of neuropeptides that modulate the transmission of nociceptive sensory information. Here, we used genetic fate mapping to show that Tlx3(+) spinal cord neurons and their derivatives represent a heterogeneous population of neurons, marked by partially overlapping expression of a set of neuropeptide genes, including those encoding the anti-opioid peptide cholecystokinin, pronociceptive Substance P (SP), Neurokinin B, and a late wave of somatostatin. Mutations of Tlx3 and Tlx1 result in a loss of expression of these peptide genes. Brn3a, a homeobox transcription factor, the expression of which is partly dependent on Tlx3, is required specifically for the early wave of SP expression. These studies suggest that Tlx1 and Tlx3 operate high in the regulatory hierarchy that coordinates specification of dorsal horn pain-modulatory peptidergic neurons. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | RAT SPINAL-CORD ; LAMINAE-I-III ; SENSORY NEURONS ; NEUROPATHIC PAIN ; GENE-EXPRESSION ; MARGINAL ZONE ; CELL FATE ; INTERNEURONS ; PHENOTYPE ; GLUTAMATE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000255012400023 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1466]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xu, Y,Lopes, C,Qian, Y,et al. Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons[J]. JOURNAL OF NEUROSCIENCE,2008,28(15):4037-4046. |
| APA | Xu, Y.,Lopes, C.,Qian, Y.,Liu, Y.,Cheng, LP.,...&Ma, QF.(2008).Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons.JOURNAL OF NEUROSCIENCE,28(15),4037-4046. |
| MLA | Xu, Y,et al."Tlx1 and Tlx3 coordinate specification of dorsal horn pain-modulatory peptidergic neurons".JOURNAL OF NEUROSCIENCE 28.15(2008):4037-4046. |
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