PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Wang, CC; Xiao, Y; Hu, ZH; Chen, YB; Liu, N; Hu, GX |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2008 |
| 卷号 | 582期号:18页码:2793-2798 |
| 关键词 | PEG10 E2F hepatocelluar carcinoma apoptosis |
| 通讯作者 | Hu, GX (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,hgxgene@sunm.shcnc.ac.cn |
| 英文摘要 | PEG10 is an imprinted gene which is up-regulated in hepatocelluar carcinoma (HCC). However, the mechanism of PEG10 regulation remains to be elucidated. In this work the transcription factors E2F-1 and -4 were demonstrated to bind directly to the promoter of PEG10 and thereby regulate its expression. The expression pro. le of HCC tissues also suggested E2Fs were involved in PEG10 regulation. Further functional analysis showed that PEG10 was involved in the repression of apoptosis induced by serum deprivation and chemotherapeutic drugs. These findings link cancer genetics and epigenetics by showing that E2F acts directly upstream of an anti-apoptosis imprinted gene, PEG10. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | GROWTH-FACTOR-BETA ; GENE-EXPRESSION ; IMPRINTED GENE ; CANCER-CELLS ; APOPTOSIS ; CARCINOGENESIS ; PROLIFERATION ; PROTEINS ; DISTINCT ; TISSUES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000258108400019 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1469]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, CC,Xiao, Y,Hu, ZH,et al. PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma[J]. FEBS LETTERS,2008,582(18):2793-2798. |
| APA | Wang, CC,Xiao, Y,Hu, ZH,Chen, YB,Liu, N,&Hu, GX.(2008).PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma.FEBS LETTERS,582(18),2793-2798. |
| MLA | Wang, CC,et al."PEG10 directly regulated by E2Fs might have a role in the development of hepatocellular carcinoma".FEBS LETTERS 582.18(2008):2793-2798. |
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