The voltage-gated Na(+) channel Na(v)1.8 contains an ER-retention/retrieval signal antagonized by the beta 3 subunit
文献类型：期刊论文
| 作者 | Zhang, ZN; Li, Q; Liu, C; Wang, HB; Wang, Q; Bao, L |
| 刊名 | JOURNAL OF CELL SCIENCE
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| 出版日期 | 2008 |
| 卷号 | 121期号:19页码:3243-3252 |
| 关键词 | Na(v)1.8 ER-retention/retrieval signal Na(+) channel beta 3 subunit |
| 通讯作者 | Bao, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,baolan@sibs.ac.cn |
| 英文摘要 | Voltage-gated Na(+) channel (Na(v)) 1.8 contributes to the majority of the Na+ current that underlies the depolarizing phase of action potentials. Na(v)1.8 is mainly distributed intracellularly and its current amplitude can be enhanced by the beta 3 subunit. However, little is known about the mechanisms underlying its intracellular retention and the effects mediated by the beta 3 subunit. Here, we show that the beta 3 subunit promotes surface expression of Na(v)1.8 by masking its endoplasmic reticulum (ER)-retention/retrieval signal. The RRR motif in the first intracellular loop of Nav1.8 is responsible for retaining Na(v)1.8 in the ER and restricting its surface expression. The beta 3 subunit facilitates surface expression of Na(v)1.8. The intracellular C-terminus of the beta 3 subunit interacts with the first intracellular loop of Na(v)1.8 and masks the ER-retention/retrieval signal. Mutation of the RRR motif results in a significant increase in surface expression of Na(v)1.8 and abolishes the beta 3-subunit-mediated effects. Thus, the beta 3 subunit regulates surface expression of Nav1.8 by antagonizing its ER-retention/retrieval signal. These results reveal a novel mechanism for the effect of the Na(+) channel beta subunits on the alpha subunits. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | SENSITIVE SODIUM-CHANNELS ; RETICULUM-RETENTION MOTIF ; ENDOPLASMIC-RETICULUM ; AUXILIARY SUBUNIT ; SENSORY NEURONS ; BETA-1 SUBUNIT ; TETRODOTOXIN-RESISTANT ; FUNCTIONAL EXPRESSION ; TRAFFICKING SIGNALS ; NEUROPATHIC PAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259288200015 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1470]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, ZN,Li, Q,Liu, C,et al. The voltage-gated Na(+) channel Na(v)1.8 contains an ER-retention/retrieval signal antagonized by the beta 3 subunit[J]. JOURNAL OF CELL SCIENCE,2008,121(19):3243-3252. |
| APA | Zhang, ZN,Li, Q,Liu, C,Wang, HB,Wang, Q,&Bao, L.(2008).The voltage-gated Na(+) channel Na(v)1.8 contains an ER-retention/retrieval signal antagonized by the beta 3 subunit.JOURNAL OF CELL SCIENCE,121(19),3243-3252. |
| MLA | Zhang, ZN,et al."The voltage-gated Na(+) channel Na(v)1.8 contains an ER-retention/retrieval signal antagonized by the beta 3 subunit".JOURNAL OF CELL SCIENCE 121.19(2008):3243-3252. |
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