Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification
文献类型：期刊论文
| 作者 | Shan, SF; Wang, LF; Zhai, JW; Qin, Y; Ouyang, HF; Kong, YY; Liu, J; Wang, Y; Xie, YH |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2008 |
| 卷号 | 582期号:27页码:3723-3728 |
| 关键词 | Prox1 Sumoylation HDAC3 Corepressor Transcription |
| 通讯作者 | Xie, YH (reprint author), Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Key Lab Med Mol Virol, Shanghai 200032, Peoples R China.,yhxie@sibs.ac.cn |
| 英文摘要 | Prospero-related homeobox protein (Prox1) plays essential roles in the development of many tissues and organs. In the present study, we show that Prox1 is modified by the small ubiquitin-like protein SUMO-1 in cultured cells. Mutation analysis identified at least four potential sumoylation sites within the repression domain of Prox1. Our data indicate that sumoylation of Prox1 reduces its interaction with HDAC3 and as a result downregulates its corepressor activity. These findings suggest that sumoylation may serve as a novel mechanism for the regulation of Prox1's corepressor activity. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | LIVER RECEPTOR HOMOLOG-1 ; ACTIVATION ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000261234800003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1475]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Shan, SF,Wang, LF,Zhai, JW,et al. Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification[J]. FEBS LETTERS,2008,582(27):3723-3728. |
| APA | Shan, SF.,Wang, LF.,Zhai, JW.,Qin, Y.,Ouyang, HF.,...&Xie, YH.(2008).Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification.FEBS LETTERS,582(27),3723-3728. |
| MLA | Shan, SF,et al."Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification".FEBS LETTERS 582.27(2008):3723-3728. |
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