Combinatorial signals of Activin/Nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells
文献类型：期刊论文
| 作者 | Wu, Z; Zhang, W; Chen, GB; Cheng, L; Liao, J; Jia, N; Gao, Y; Dai, HM; Yuan, JD; Cheng, LZ |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
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| 出版日期 | 2008 |
| 卷号 | 283期号:36页码:24991-25002 |
| 通讯作者 | Xiao, L (reprint author), 320 Yue Yang Rd,Bldg 41,Rm 625, Shanghai 200031, Peoples R China.,leixiao@sibs.ac.cn |
| 英文摘要 | Cell fate commitment of pre-implantation blastocysts, to either the inner cell mass or trophoblast, is the first step in cell lineage segregation of the developing human embryo. However, the intercellular signals that control fate determination of these cells remain obscure. Human embryonic stem cells (hESCs) provide a unique model for studying human early embryonic development. We have previously shown that Activin/Nodal signaling contributes to maintaining pluripotency of hESCs, which are derivatives of the inner cell mass. Here we further demonstrate that the inhibition of Activin/Nodal signaling results in the loss of hESC pluripotency and trophoblast differentiation, similar to BMP4-induced trophoblast differentiation from hESCs. We also show that the trophoblast induction effect of BMP4 correlates with and depends on the inhibition of Activin/Nodal signaling. However, the activation of BMP signaling is still required for trophoblast differentiation when Activin/Nodal signaling is inhibited. These data reveal that the early lineage segregation of hESCs is determined by the combinatorial signals of Activin/Nodal and BMP. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | FIBROBLAST-GROWTH-FACTOR ; SELF-RENEWAL ; HUMAN BLASTOCYSTS ; MOUSE EMBRYO ; IN-VITRO ; DIFFERENTIATION ; PLURIPOTENCY ; TROPHOBLAST ; INHIBITION ; MAINTAINS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000258820000059 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1479]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wu, Z,Zhang, W,Chen, GB,et al. Combinatorial signals of Activin/Nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2008,283(36):24991-25002. |
| APA | Wu, Z.,Zhang, W.,Chen, GB.,Cheng, L.,Liao, J.,...&Xiao, L.(2008).Combinatorial signals of Activin/Nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells.JOURNAL OF BIOLOGICAL CHEMISTRY,283(36),24991-25002. |
| MLA | Wu, Z,et al."Combinatorial signals of Activin/Nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells".JOURNAL OF BIOLOGICAL CHEMISTRY 283.36(2008):24991-25002. |
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