Negative Regulation of Virus-triggered IFN-beta Signaling Pathway by Alternative Splicing of TBK1
文献类型：期刊论文
| 作者 | Deng, WW; Shi, MD; Han, MF; Zhong, J; Li, ZH; Li, WN; Hu, Y; Yan, LC; Wang, J; He, Y |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2008 |
| 卷号 | 283期号:51页码:35590-35597 |
| 通讯作者 | Ning, Q (reprint author), Huazhong Univ Sci & Technol, Tongji Hosp Tongji, Coll Med, Dept Infect Dis, Wuhan 430030, Peoples R China.,qning@tjh.tjmu.edu.cn ; bsun@sibs.ac.cn |
| 英文摘要 | Induction of Type I IFNs is a central event in antiviral responses and must be tightly controlled. The protein kinase TBK1 is critically involved in virus-triggered type I IFN signaling. In this study, we identify an alternatively spliced isoform of TBK1, termed TBK1s, which lacks exons 3-6. Upon Sendai virus (SeV) infection, TBK1s is induced in both human and mouse cells and binds to RIG-1, disrupting the interaction between RIG-I and VISA. Consistent with that result, overexpression of TBK1s inhibits IRF3 nuclear translocation and leads to a shutdown of SeV-triggered IFN-beta production. Taken together, our data indicate that TBK1s plays an inhibitory role in virus-triggered IFN-beta signaling pathways. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | NF-KAPPA-B ; DOUBLE-STRANDED-RNA ; TANK-BINDING KINASE-1 ; EPSTEIN-BARR-VIRUS ; RIG-I ; ANTIVIRAL RESPONSES ; GENE-TRANSCRIPTION ; UBIQUITIN LIGASE ; VIRAL-INFECTION ; ADAPTER PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000261687900031 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1481]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Deng, WW,Shi, MD,Han, MF,et al. Negative Regulation of Virus-triggered IFN-beta Signaling Pathway by Alternative Splicing of TBK1[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2008,283(51):35590-35597. |
| APA | Deng, WW.,Shi, MD.,Han, MF.,Zhong, J.,Li, ZH.,...&Sun, B.(2008).Negative Regulation of Virus-triggered IFN-beta Signaling Pathway by Alternative Splicing of TBK1.JOURNAL OF BIOLOGICAL CHEMISTRY,283(51),35590-35597. |
| MLA | Deng, WW,et al."Negative Regulation of Virus-triggered IFN-beta Signaling Pathway by Alternative Splicing of TBK1".JOURNAL OF BIOLOGICAL CHEMISTRY 283.51(2008):35590-35597. |
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