The physical and functional interaction of NDRG2 with MSP58 in cells
文献类型：期刊论文
| 作者 | Zhang, J; Liu, JY; Li, X; Li, FY; Wang, LF; Zhang, J; Liu, XP; Shen, L; Liu, N; Deng, YC |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2007 |
| 卷号 | 352期号:1页码:42166 |
| 关键词 | Ndrg2 yeast two-hybrid MSP58 cell cycle regulation |
| 通讯作者 | Yao, LB (reprint author), Fourth Mil Med Univ, Dept Biochem & Mol Biol, Xian 710032, Peoples R China.,bioyao@fmmu.edu.cn |
| 英文摘要 | NDRG2, a member of N-Myc downstream regulated gene family, exerts the important functions in cell differentiation and tumor suppression. Although the ectopic expressed Ndrg2 inhibits the proliferation of tumor cells, its intracellular signal transduction pathway is hardly known. Here, we identified MSP58, a 58-kDa microspherule protein, as an interacting partner of human Ndrg2 by using yeast two-hybrid screening. The interaction was confirmed by glutathione S-transferase pull-down assay in vitro and by co-immune-precipitation assay in vivo. The forkhead associated domain of MSP58 is essential for its interaction with Ndrg2. Ndrg2 could co-localize with MSP58 in nuclear of HeLa cell during cell stress. Furthermore, the modulation of Ndrg2 level influences the cell cycle process together with MSP58. In conclusion, the findings offered a novel insight into the physiological roles of Ndrg2. (c) 2006 Published by Elsevier Inc. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | DOWNSTREAM-REGULATED GENE-2 ; 58-KDA MICROSPHERULE PROTEIN ; TUMOR-SUPPRESSOR ; MAST-CELLS ; FHA DOMAIN ; EXPRESSION ; DIFFERENTIATION ; TRANSCRIPTION ; CANCER ; DRG-1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000243056700002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1507]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, J,Liu, JY,Li, X,et al. The physical and functional interaction of NDRG2 with MSP58 in cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,352(1):42166. |
| APA | Zhang, J.,Liu, JY.,Li, X.,Li, FY.,Wang, LF.,...&Yao, LB.(2007).The physical and functional interaction of NDRG2 with MSP58 in cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,352(1),42166. |
| MLA | Zhang, J,et al."The physical and functional interaction of NDRG2 with MSP58 in cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 352.1(2007):42166. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。