HF-LANa, a human homologue of Derlin family, regulating the expression of cancer-related genes promotes NIH3T3 cell transformation
文献类型：期刊论文
| 作者 | Hu, YH; Ying, H; Xu, YH |
| 刊名 | CANCER LETTERS
 |
| 出版日期 | 2007 |
| 卷号 | 258期号:2页码:171-180 |
| 关键词 | hF-LANa Transformation oncogene/proto-oncogene tumor suppressor gene mouse oligo cDNA expression assay |
| 通讯作者 | Xu, YH (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol,Lab Mol & Cellular Oncol, 320 YueYang Rd, Shanghai 200031, Peoples R China.,yhxu@sibs.ac.cn |
| 英文摘要 | hF-LANa, a member of Derlin family, is a putative proto-oncogene and has a direct role in oncogenic transformation. hF-LANa over-expressed NIH3T3 cells grow 20% quicker than parent cells. Especially, hF-LANa over-expression promotes anchorage-independent growth of NIH3T3 cells in soft agar and tumorigenesis in nude mice. Analysis by cDNA microarray finds 252 up-regulated genes and 354 down-regulated genes in hF-LANa over-expressed NIH3T3 cells including 19 oncogenes/proto-oncogenes and 13 tumor suppressor genes/putative tumor suppressors. These experiments show the oncogenic transformation role of hF-LANa both in vitro and in vivo, and highlight the genes that might be related to hF-LANa's oncogenic effects. (c) 2007 Published by Elsevier Ireland Ltd. |
| 学科主题 | Oncology |
| 类目[WOS] | Oncology |
| 关键词[WOS] | ENDOPLASMIC-RETICULUM MEMBRANE ; HEPATOCELLULAR-CARCINOMA ; MISFOLDED PROTEINS ; DEGRADATION ; GROWTH ; RB ; ER ; IDENTIFICATION ; TUMORIGENESIS ; DISLOCATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000251852600003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1517]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hu, YH,Ying, H,Xu, YH. HF-LANa, a human homologue of Derlin family, regulating the expression of cancer-related genes promotes NIH3T3 cell transformation[J]. CANCER LETTERS,2007,258(2):171-180. |
| APA | Hu, YH,Ying, H,&Xu, YH.(2007).HF-LANa, a human homologue of Derlin family, regulating the expression of cancer-related genes promotes NIH3T3 cell transformation.CANCER LETTERS,258(2),171-180. |
| MLA | Hu, YH,et al."HF-LANa, a human homologue of Derlin family, regulating the expression of cancer-related genes promotes NIH3T3 cell transformation".CANCER LETTERS 258.2(2007):171-180. |
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