Homeostatic plasticity of GABAergic synaptic transmission in mice lacking GAT1
文献类型：期刊论文
| 作者 | Xu, YF; Cai, YQ; Gong, N; Chen, C; Wu, Y; Sandy, ZN; Wang, ZG; Xu, TL; Fei, J |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2007 |
| 卷号 | 361期号:2页码:499-504 |
| 关键词 | GABA transporter tiagabine knockout |
| 通讯作者 | Fei, J (reprint author), Tongji Univ, Sch Life Sci & Technol, 1239 Shiping Rd, Shanghai 200092, Peoples R China.,jfei@mail.tongji.edu.cn |
| 英文摘要 | GABA transporter-1 (GAT1) plays a key role in GABA reuptake, and deletion of GAT1 leads to a largely increased GABA-induced tonic conductance in the GATI-1- mice. We hypothesized that homeostatic plasticity of GABA(A) receptor-mediated inhibition takes place to balance the increased tonic inhibition and maintains stability of the nervous system. In this study, we employed the loss of righting reflex assay and compared the behavioral difference of three animal models, mice with acute, partial, and permanent GAT1 deficiency, to confirm our hypothesis. Our data demonstrated that both acute and partial block of GAT1 increased the sensitivity of mice to GABAergic sedative/hypnotic drugs, whereas permanent GAT1 dysfunction in the GATI-1- mice decreased the sensitivity to some extent. These results confirmed our presumption about the down-regulation of phasic GABAergic transmission in the GATI knockout mice. Moreover, electrophysiological measurements performed on slices from motor cortex suggested that it was the reduced GABA release, but not change of postsynaptic GABA receptors, which led to the down-regulation of phasic inhibition in GAT1(-/-) mice. (c) 2007 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | GABA(A) RECEPTORS ; NEURONAL EXCITABILITY ; TONIC ACTIVATION ; SUBUNIT ; INHIBITION ; DELETION ; ETHANOL ; ALPHA-1 ; TRANSPORTERS ; PHARMACOLOGY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248738400040 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1518]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xu, YF,Cai, YQ,Gong, N,et al. Homeostatic plasticity of GABAergic synaptic transmission in mice lacking GAT1[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,361(2):499-504. |
| APA | Xu, YF.,Cai, YQ.,Gong, N.,Chen, C.,Wu, Y.,...&Fei, J.(2007).Homeostatic plasticity of GABAergic synaptic transmission in mice lacking GAT1.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,361(2),499-504. |
| MLA | Xu, YF,et al."Homeostatic plasticity of GABAergic synaptic transmission in mice lacking GAT1".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 361.2(2007):499-504. |
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