Wnt/beta-catenin signaling controls Mespo expression to regulate segmentation during Xenopus somitogenesis
文献类型：期刊论文
| 作者 | Wang, JH; Li, SW; Chen, YL; Ding, XY |
| 刊名 | DEVELOPMENTAL BIOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 304期号:2页码:836-847 |
| 关键词 | AKT paraxial mesoderm PI3-K Wnt Xenopus laevis |
| 通讯作者 | Ding, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Stem Cell Biol, Inst Biochem & Cell Biol,Lab Mol Cell Biol, Shanghai 200031, Peoples R China.,xyding@sunm.shcnc.ac.cn |
| 英文摘要 | The vertebral column is derived from somites, which are transient segments of the paraxial mesoderm that are present in developing vertebrates. The strict spatial and temporal regulation of somitogenesis is of crucial developmental importance. Signals such as Wnt and FGF play roles in somitogenesis, but details regarding how Wnt signaling functions in this process remain unclear. In this study, we report that Wnt/beta-catenin signaling regulates the expression of Mespo, a basic-helix-loop-helix (bHLH) gene critical for segmental patterning in Xenopus somitogenesis. Transgenic analysis of the Mespo promoter identifies Mespo as a direct downstream target of Wnt/beta-catenin signaling pathway. We also demonstrate that activity of Wnt/-catenin. signaling in somitogenesis can be enhanced by the PI3-K/AKT pathway. Our results illustrate that Wnt/-catenin signaling in conjunction with PI3-K/AKT pathway plays a key role in controlling development of the paraxial mesoderm. (c) 2007 Published by Elsevier Inc. |
| 学科主题 | Developmental Biology |
| 类目[WOS] | Developmental Biology |
| 关键词[WOS] | PARAXIAL MESODERM ; PRESOMITIC MESODERM ; MOUSE EMBRYO ; BETA-CATENIN ; SPECIFICATION ; INDUCTION ; BRACHYURY ; SOMITE ; CLOCK ; FGF |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000245819600031 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1523]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, JH,Li, SW,Chen, YL,et al. Wnt/beta-catenin signaling controls Mespo expression to regulate segmentation during Xenopus somitogenesis[J]. DEVELOPMENTAL BIOLOGY,2007,304(2):836-847. |
| APA | Wang, JH,Li, SW,Chen, YL,&Ding, XY.(2007).Wnt/beta-catenin signaling controls Mespo expression to regulate segmentation during Xenopus somitogenesis.DEVELOPMENTAL BIOLOGY,304(2),836-847. |
| MLA | Wang, JH,et al."Wnt/beta-catenin signaling controls Mespo expression to regulate segmentation during Xenopus somitogenesis".DEVELOPMENTAL BIOLOGY 304.2(2007):836-847. |
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