中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海生物化学与细胞生物学研究所
  3. 上海生科院生化细胞研究所
beta-arrestin signaling and regulation of transcription

文献类型：期刊论文

作者Ma, L; Pei, G
刊名JOURNAL OF CELL SCIENCE
出版日期2007
卷号120期号:2页码:213-218
关键词beta-arrestins G-protein-coupled receptors transcription signal transduction
通讯作者Ma, L (reprint author), Fudan Univ, Pharmacol Res Ctr, Shanghai Med Coll, 138 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China.,lanma@fudan.edu.cn ; gpei@sibs.ac.cn
英文摘要beta-arrestin 1 and beta-arrestin 2 are well-known negative regulators of G-protein-coupled receptor ( GPCR) signaling. Upon GPCR activation, beta-arrestins translocate to the cell membrane and bind to the agonist-occupied receptors. This uncouples these receptors from G proteins and promotes their internalization, thus causing desensitization. However, accumulating evidence indicates that beta-arrestins also function as scaffold proteins that interact with several cytoplasmic proteins and link GPCRs to intracellular signaling pathways such as MAPK cascades. Recent work has also revealed that, in response to activation of certain GPCRs, beta-arrestins translocate from the cytoplasm to the nucleus and associate with transcription cofactors such as p300 and cAMP-response element-binding protein ( CREB) at the promoters of target genes to promote transcription. They also interact with regulators of transcription factors, such as I kappa B alpha and MDM2, in the cytoplasm and regulate transcription indirectly. This beta-arrestin-mediated regulation of transcription appears to play important roles in cell growth, apoptosis and modulation of immune functions.
学科主题Cell Biology
类目[WOS]Cell Biology
关键词[WOS]PROTEIN-COUPLED RECEPTORS ; NUCLEAR EXPORT SIGNAL ; ADRENERGIC-RECEPTOR ; ERK1/2 ACTIVATION ; BETA-ARRESTIN2 ; KINASE ; PATHWAYS ; PHOSPHORYLATION ; OLIGOMERIZATION ; LOCALIZATION
收录类别SCI
语种英语
WOS记录号WOS:000243723900002
版本出版稿
源URL[http://202.127.25.143/handle/331003/1533]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714		 Ma, L,Pei, G. beta-arrestin signaling and regulation of transcription[J]. JOURNAL OF CELL SCIENCE,2007,120(2):213-218.
APA Ma, L,&Pei, G.(2007).beta-arrestin signaling and regulation of transcription.JOURNAL OF CELL SCIENCE,120(2),213-218.
MLA Ma, L,et al."beta-arrestin signaling and regulation of transcription".JOURNAL OF CELL SCIENCE 120.2(2007):213-218.

入库方式： OAI收割

来源：上海生物化学与细胞生物学研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。