Molecular mechanism of abnormal aggregation of alpha-synuclein
文献类型：期刊论文
| 作者 | Hu, H; Lin, X |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2007 |
| 卷号 | 52期号:2页码:159-164 |
| 关键词 | alpha-synuclein aggregation molecular mechanism Parkinson's disease |
| 通讯作者 | Hu, H (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,hyhu@sibs.ac.cn |
| 英文摘要 | The abnormal aggregation of alpha-synuclein (alpha-Syn) is thought to be closely associated with Parkinson's disease, but the pathogenesis is still unclear. In this review, we survey the latest development in the molecular mechanism of abnormal alpha-Syn aggregation, especially in the aspects of the core sequences, aggregation inhibitors, structural transformation and filament morphologies. By exploring the mechanism of alpha-Syn aggregation, we will have a better understanding of the disease pathogenesis, and develop strategies for preventing and treating this severe disease. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | ATOMIC-FORCE MICROSCOPY ; PARKINSONS-DISEASE ; BETA-SHEET ; CIRCULAR-DICHROISM ; SECONDARY STRUCTURE ; AMYLOID PROTEINS ; SOLID-STATE ; FIBRILS ; FIBRILLIZATION ; COMPONENT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000245638500002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1534]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hu, H,Lin, X. Molecular mechanism of abnormal aggregation of alpha-synuclein[J]. CHINESE SCIENCE BULLETIN,2007,52(2):159-164. |
| APA | Hu, H,&Lin, X.(2007).Molecular mechanism of abnormal aggregation of alpha-synuclein.CHINESE SCIENCE BULLETIN,52(2),159-164. |
| MLA | Hu, H,et al."Molecular mechanism of abnormal aggregation of alpha-synuclein".CHINESE SCIENCE BULLETIN 52.2(2007):159-164. |
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