Male germ cell-specific expression of a novel Patched-domain containing gene Ptchd3
文献类型：期刊论文
| 作者 | Fan, J; Akabane, H; Zheng, XH; Zhou, XA; Zhang, L; Liu, Q; Zhang, YL; Yang, J; Zhu, GZ |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2007 |
| 卷号 | 363期号:3页码:757-761 |
| 关键词 | Ptchd3 hedgehog signaling patched male germ cell-specific sperm midpiece |
| 通讯作者 | Zhu, GZ (reprint author), Marshall Univ, Dept Sci Biol, Huntington, WV 25755 USA.,zhu4@marshall.edu |
| 英文摘要 | The Hedgehog (Hh) signaling pathway plays an important role in various biological processes, including pattern formation, cell fate determination, proliferation, and differentiation. Hh function is mediated through its membrane receptor Patched. Herein, we have characterized a novel Patched-domain containing gene Ptchd3 in mouse. Messenger RNA of Ptchd3 was exclusively detected in the testis, and existed in two isoforms Ptchd3a, and Ptchd3b. The expression of these two mRNA isoforms was shown to be developmentally regulated in testes, and specifically found in male germ cells. Further analysis revealed that the Ptchd3 protein was located on the midpiece of mouse, rat and human sperm. Collectively, these results indicate that Ptchd3 is a novel male germ cell-specific gene and may be involved in the Hh signaling to regulate sperm development and/or sperm function. (C) 2007 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology ; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | TRANSGENIC MICE ; MOUSE TESTIS ; HEDGEHOG ; PATHWAY ; LOCALIZATION ; EPIDIDYMIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000250359400051 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1536]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Fan, J,Akabane, H,Zheng, XH,et al. Male germ cell-specific expression of a novel Patched-domain containing gene Ptchd3[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,363(3):757-761. |
| APA | Fan, J.,Akabane, H.,Zheng, XH.,Zhou, XA.,Zhang, L.,...&Zhu, GZ.(2007).Male germ cell-specific expression of a novel Patched-domain containing gene Ptchd3.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,363(3),757-761. |
| MLA | Fan, J,et al."Male germ cell-specific expression of a novel Patched-domain containing gene Ptchd3".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 363.3(2007):757-761. |
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