Inhibitive effects of Fructus Psoraleae extract on dopamine transporter and noradrenaline transporter
文献类型：期刊论文
| 作者 | Zhao, G; Li, S; Qin, GW; Fei, JA; Guo, LH |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 112期号:3页码:498-506 |
| 关键词 | Fructus Psoraleae extract dopamine transporter noradrenaline transporter reuptake inhibitor |
| 通讯作者 | Guo, LH (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,lhguo@sibs.ac.cn |
| 英文摘要 | A petroleum ether extract (FP) from Fructus Psoraleae, seeds of Psoralea corylifolia L. (Leguminosae), was found to strongly inhibit dopamine (DA) uptake by dopamine transporter (DAT) heterogeneously expressed cells (D8 cells) and noradrenaline (NE) uptake by noradrenaline transporter (NET) heterogeneously expressed cells, which, however, had no effect on gamma-aminobutyric acid transporter heterogeneously expressed cells and serotonin transporter heterogeneously expressed cells at the concentration up to 100 mu g/ml. These inhibitory effects were also confirmed by experiments on SK-N-SH cell line and synaptosomes from rats' brains. In addition, FP showed a significantly mitigating effect on 1-methyl-4-pyridinium induced injury of D8 cells. Meanwhile, FP dose-dependently reduced the binding of tritium-labeled cocaine analog (-)-2 beta-carbornethoxy-3 beta-(4-fluorophenyl) tropane to DAT of D8 cells, which suggests that FP may inhibit DAT activity in the same way as cocaine does. Behavioral study showed FP had a long-lasting stimulant effects on the activity of intact mice and reserpinized mice. So FP is proposed as a kind of DAT and NET inhibitor and may be involved in the process of regulating the DA and NE system, and FP or its unknown bioactive compounds may be developed into new medicines for disorders such as Parkinson's disease, depression, Attention Deficit Hyperactivity Disorder (ADHD) or cocaine addiction. (c) 2007 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 关键词[WOS] | RAT-BRAIN ; MICE ; DEGENERATION ; MECHANISMS ; SEROTONIN ; RESPONSES ; COCAINE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248467200012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1538]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, G,Li, S,Qin, GW,et al. Inhibitive effects of Fructus Psoraleae extract on dopamine transporter and noradrenaline transporter[J]. JOURNAL OF ETHNOPHARMACOLOGY,2007,112(3):498-506. |
| APA | Zhao, G,Li, S,Qin, GW,Fei, JA,&Guo, LH.(2007).Inhibitive effects of Fructus Psoraleae extract on dopamine transporter and noradrenaline transporter.JOURNAL OF ETHNOPHARMACOLOGY,112(3),498-506. |
| MLA | Zhao, G,et al."Inhibitive effects of Fructus Psoraleae extract on dopamine transporter and noradrenaline transporter".JOURNAL OF ETHNOPHARMACOLOGY 112.3(2007):498-506. |
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