Possible role of histone H1 in the regulation of furin-dependent proprotein processing
文献类型：期刊论文
| 作者 | Han, JB; Gu, JX; Chi, CW |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2007 |
| 卷号 | 39期号:3页码:173-180 |
| 关键词 | furin histone H1 pro-vWF proprotein processing |
| 通讯作者 | Chi, CW (reprint author), Chinese Acad Sci, Grad Sch, Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,chi@sunm.shcnc.ac.cn |
| 英文摘要 | Histone H1 and its C-terminal lysine rich fragments were recently found to be potent inhibitors of furin, a mammalian proprotein convertase. However, its role in the regulation of furin-dependent proprotein processing remains unclear. Here we report that histone H1 efficiently blocks furin-dependent pro-von Willebrand factor (pro-vWF) processing in a dose-dependent manner. Coimmunoprecipitation and immunofluorescence studies confirmed that histone H1 could interact with furin, and the interaction mainly took place on the cell surface. We noted that histone H1 was released from cells undergoing necrosis and apoptosis induced by H2O2. Our findings suggested that histone H1 might be involved in extracellular and/or intracellular furin regulation. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | BREAST-CANCER ; CELL-SURFACE ; INHIBITOR ; CONVERTASES ; PROTEINS ; PROTEASE ; POTENT ; INVOLVEMENT ; MODULATION ; ACTIVATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000244877600003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1540]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Han, JB,Gu, JX,Chi, CW. Possible role of histone H1 in the regulation of furin-dependent proprotein processing[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2007,39(3):173-180. |
| APA | Han, JB,Gu, JX,&Chi, CW.(2007).Possible role of histone H1 in the regulation of furin-dependent proprotein processing.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,39(3),173-180. |
| MLA | Han, JB,et al."Possible role of histone H1 in the regulation of furin-dependent proprotein processing".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 39.3(2007):173-180. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。