Expression and functional analysis of the cellular retinoic acid binding protein from silkworm pupae (Bombyx mori)
文献类型：期刊论文
| 作者 | Wang, XJ; Chen, J; Lv, ZB; Nie, ZM; Wang, D; Shen, HD; Wang, XD; Wu, XF; Zhang, YZ |
| 刊名 | JOURNAL OF CELLULAR BIOCHEMISTRY
 |
| 出版日期 | 2007 |
| 卷号 | 102期号:4页码:970-979 |
| 关键词 | Bombyx mori cellular retinoic acid binding protein all-trans retinoic acid subcellular localization |
| 通讯作者 | Zhang, YZ (reprint author), Zhejiang Sci Tech Univ, Coll Life Sci, Inst Biochem, Hangzhou 310018, Peoples R China.,yaozhou@chinagene.com |
| 英文摘要 | Cellular retinoic acid binding protein (CRABP) is a member of intracellular lipid-binding protein (iLBP), and closely associated with retinoic acid (RA) activity. We have cloned the CRABP gene from silkworm pupae and studied the interaction between Bombyx mori CRABP (BmCRABP) and all-trans retinoic acid (atRA). The MTT assay data indicated that when BmCRABP is overexpressed in Bm5 cells, the cells dramatically resisted to atRA-induced growth inhibition. Conversely, the cells were sensitive to atRA treatment upon knocking down the BmCRABP expression. Subcellular localization revealed that BmCRABP is a cytoplasm protein, even when treated with atRA, the CRABP still remained in the cytoplasm. These data demonstrated that the function of BmCRABP have an effect on the physiological function of atRA. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | ACUTE-PROMYELOCYTIC-LEUKEMIA ; ALL-TRANS ; PREMALIGNANT LESIONS ; GENE-EXPRESSION ; THYROID-HORMONE ; I EXPRESSION ; RXR-BETA ; CARCINOMA ; RECEPTOR ; CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000250637600017 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1546]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, XJ,Chen, J,Lv, ZB,et al. Expression and functional analysis of the cellular retinoic acid binding protein from silkworm pupae (Bombyx mori)[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2007,102(4):970-979. |
| APA | Wang, XJ.,Chen, J.,Lv, ZB.,Nie, ZM.,Wang, D.,...&Zhang, YZ.(2007).Expression and functional analysis of the cellular retinoic acid binding protein from silkworm pupae (Bombyx mori).JOURNAL OF CELLULAR BIOCHEMISTRY,102(4),970-979. |
| MLA | Wang, XJ,et al."Expression and functional analysis of the cellular retinoic acid binding protein from silkworm pupae (Bombyx mori)".JOURNAL OF CELLULAR BIOCHEMISTRY 102.4(2007):970-979. |
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