Inhibition of tumor growth in mice by endostatin derived from abdominal transplanted encapsulated cells
文献类型：期刊论文
| 作者 | Teng, HN; Zhang, Y; Wang, W; Ma, XJ; Fei, J |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2007 |
| 卷号 | 39期号:4页码:278-284 |
| 关键词 | microencapsulation endostatin CHO tumor gene therapy |
| 通讯作者 | Ma, XJ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Model Organism Res Ctr,Lab Mol Cell Biol, Shanghai 200031, Peoples R China.,maxj@dicp.ac.cn ; jfei@sibs.ac.cn |
| 英文摘要 | Endostatin, a C-terminal fragment of collagen 18a, inhibits the growth of established tumors and metastases in vivo by inhibiting angiogenesis. However, the purification procedures required for large-scale production and the attendant cost of these processes, together with the low effectiveness in clinical tests, suggest that alternative delivery methods might be required for efficient therapeutic use of endostatin. In the present study, we transfected Chinese hamster ovary (CHO) cells with a human endostatin gene expression vector and encapsulated the CHO cells in alginate-poly-L-lysine microcapsules. The release of biologically active endostatin was confirmed using the chicken chorioallantoic membrane assay. The encapsulated endostatin-expressing CHO cells can inhibit the growth of primary tumors in a subcutaneous B16 tumor model when injected into the abdominal cavity of mouse. These results widen the clinical application of the microencapsulated cell endostatin delivery system in cancer treatment. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | ANGIOGENESIS INHIBITOR ; RECOMBINANT CELLS ; GENE-THERAPY ; ALGINATE ; MICROENCAPSULATION ; CANCER ; IMMUNOSUPPRESSION ; BIOCOMPATIBILITY ; DELIVERY ; BINDING |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000245741000006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1551]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Teng, HN,Zhang, Y,Wang, W,et al. Inhibition of tumor growth in mice by endostatin derived from abdominal transplanted encapsulated cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2007,39(4):278-284. |
| APA | Teng, HN,Zhang, Y,Wang, W,Ma, XJ,&Fei, J.(2007).Inhibition of tumor growth in mice by endostatin derived from abdominal transplanted encapsulated cells.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,39(4),278-284. |
| MLA | Teng, HN,et al."Inhibition of tumor growth in mice by endostatin derived from abdominal transplanted encapsulated cells".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 39.4(2007):278-284. |
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