IFITM1 plays an essential role in the antiproliferative action of interferon-gamma
文献类型：期刊论文
| 作者 | Yang, G; Xu, Y; Chen, X; Hu, G |
| 刊名 | ONCOGENE
 |
| 出版日期 | 2007 |
| 卷号 | 26期号:4页码:594-603 |
| 关键词 | control of cell cycle progression IFITM1 interferon-gamma p53 extracellular signal-regulated kinase |
| 通讯作者 | Hu, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,hgxgene@sunm.shcnc.ac.cn |
| 英文摘要 | Interferon-gamma (IFN-gamma) is a pleiotropic cytokine involved in antiproliferative and anti-virus responses, immune surveillance and tumor suppression. These biological responses to IFN-gamma are mainly mediated by the regulation of gene expression. It has been reported that growth-inhibitory role of IFN-gamma is dependent on activation of signal transducers and activators of transcription 1 (STAT1); however, the molecular basis downstream of STAT1 remains unclear. Here, we report that an IFN-gamma-induced gene, interferon-induced transmembrane protein 1 (IFITM1), plays a key role in the antiproliferative action of IFN-gamma. Overexpression of IFITM1 negatively regulated cell growth, whereas suppression of IFITM1 blocked the antiproliferative effect of IFN-gamma, accelerated the cell growth rate and conferred tumorigenicity to a nonmalignant hepatocyte in nude mice. Further, IFITM1 could inhibit the activity of extracellular signal-regulated kinase, enhance the transcriptional activity of p53 and stabilize the p53 protein by inhibiting p53 phosphorylation on Thr55. Suppression of p53 reduced the growth-inhibitory capacity of both IFITM1 and IFN-gamma. Therefore, these findings indicated that the antiproliferative action of IFN-gamma requires the induction of IFITM1, and provided a crosstalk between two well-known signaling mediators, STAT1 and p53, both of which play critical roles in tumor suppression. |
| 学科主题 | Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| 类目[WOS] | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| 关键词[WOS] | SIGNAL-TRANSDUCTION PATHWAYS ; BREAST-CANCER PROGRESSION ; CYCLIN-DEPENDENT KINASE ; MYC MESSENGER-RNA ; GENE-EXPRESSION ; TRANSCRIPTIONAL ACTIVATION ; DOWN-REGULATION ; CELL-GROWTH ; C-MYC ; DIFFERENTIAL RESPONSE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000243731600011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1560]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yang, G,Xu, Y,Chen, X,et al. IFITM1 plays an essential role in the antiproliferative action of interferon-gamma[J]. ONCOGENE,2007,26(4):594-603. |
| APA | Yang, G,Xu, Y,Chen, X,&Hu, G.(2007).IFITM1 plays an essential role in the antiproliferative action of interferon-gamma.ONCOGENE,26(4),594-603. |
| MLA | Yang, G,et al."IFITM1 plays an essential role in the antiproliferative action of interferon-gamma".ONCOGENE 26.4(2007):594-603. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。