CCL19 and CXCL13 synergistically regulate interaction between B cell acute lymphocytic leukemia CD23(+) CD5(+) B cells and CD8(+) T cells
文献类型：期刊论文
| 作者 | Wang, XB; Yuling, H; Yanping, J; Xinti, T; Yaofang, Y; Feng, Y; Ruijin, X; Li, W; Lang, C; Jingyi, L |
| 刊名 | JOURNAL OF IMMUNOLOGY
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| 出版日期 | 2007 |
| 卷号 | 179期号:5页码:2880-2888 |
| 通讯作者 | Jinquan, T (reprint author), Anhui Med Univ, Prov Hosp, Dept Hematol, Hefei, Peoples R China.,jinquan_tan@hotmail.com |
| 英文摘要 | Interacting with T cells, cytokine-producing B cells play a critical protective role in autoimmune diseases. However, the interaction between malignant B and T cells remains to be fully elucidated. In a previous study, we have reported that ligation of CCL19-CCR7 and CXCL13-CXCR5 activates paternally expressed gene 10 (PEG10), resulting in an enhancement of apoptotic resistance in B-cell acute lymphocytic leukemia (B-ALL) CD23(+)CD5(+) B cells. Here, we report that B-ALL CD23(+)CD5(+) B cells produce IL-10 at high level, which can be further elevated by costimulation with CCL19 and CXCL13. CCL19/CXCL13-activated B-ALL CD23(+)CD5(+) B cells, in turn, increase IL-10 expression in syngeneic CD8(+) T cells in a B cell-derived IL-10-dependent manner and requiring a cell-cell contact. IL-10 secreted from B-ALL CD23(+)CD5(+) B cells in vitro impairs tumor-specific CTL responses of syngeneic CD8(+) T cells. The impairment of cytotoxicity of syngeneic CD8(+) T cells is escalated by means of CCL19/CXCL13-induced up-regulation of IL-10 from B-ALL CD23(+)CD5(+) B cells. Moreover, using a short hairpin RNA to knockdown PEG10, we provide direct evidence that increased expression of PEG10 in B-ALL CD23(+)CD5(+) B cells is involved in malignant B-T cell interaction, contributing to the up-regulation of IL-10 expression, as well as to-the impairment of cytotoxicity of syngeneic CD8(+) T cells. Thus, malignant B-ALL CD23(+)CD5(+) B cells play an immunoregulatory role in controlling different inflammatory cytokine expressions. IL-10 may be one of the critical cellular factors conferring B-ALL CD23(+)CD5(+) B cells to escape from host immune surveillance. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | HIGH ENDOTHELIAL VENULES ; CHEMOKINE RECEPTOR CCR7 ; HUMAN DENDRITIC CELLS ; LYMPH-NODES ; STROMAL CELLS ; UP-REGULATION ; EXPRESSION ; GENE ; MIGRATION ; CANCER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248991800028 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1563]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, XB,Yuling, H,Yanping, J,et al. CCL19 and CXCL13 synergistically regulate interaction between B cell acute lymphocytic leukemia CD23(+) CD5(+) B cells and CD8(+) T cells[J]. JOURNAL OF IMMUNOLOGY,2007,179(5):2880-2888. |
| APA | Wang, XB.,Yuling, H.,Yanping, J.,Xinti, T.,Yaofang, Y.,...&Jinquan, T.(2007).CCL19 and CXCL13 synergistically regulate interaction between B cell acute lymphocytic leukemia CD23(+) CD5(+) B cells and CD8(+) T cells.JOURNAL OF IMMUNOLOGY,179(5),2880-2888. |
| MLA | Wang, XB,et al."CCL19 and CXCL13 synergistically regulate interaction between B cell acute lymphocytic leukemia CD23(+) CD5(+) B cells and CD8(+) T cells".JOURNAL OF IMMUNOLOGY 179.5(2007):2880-2888. |
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