Differentiation of liver cells from human primordial germ cell-derived progenitors
文献类型：期刊论文
| 作者 | Chen, B; Shi, JJ; Zheng, JK; Chen, Y; Wang, K; Yang, QZ; Chen, XJ; Yang, ZQ; Zhou, XF; Zhu, YM |
| 刊名 | DIFFERENTIATION
 |
| 出版日期 | 2007 |
| 卷号 | 75期号:5页码:350-359 |
| 关键词 | differentiation human primordial germ cell-derived progenitors hepatocyte |
| 通讯作者 | Sheng, HZ (reprint author), Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Ctr Dev Biol, 1665 Kong Jiang Rd, Shanghai 200092, Peoples R China.,hzsheng2003@yahoo.com |
| 英文摘要 | In previous studies, progenitor embryoid body-derived (EBD) cells have been derived from human embryonic germ cells. These cells express lineage markers of three primary germ layers, although their potential to produce true fetal cells of various types has yet to be tested. To this end, we have transplanted EBD cells into the fetal sheep liver. We show that these cells respond appropriately to environmental cues and give rise to hepatocytes and well-structured bile ducts. These results suggest that EBD cells are relatively uncommitted early progenitors capable of effective incorporation and differentiation in vivo. The ability to generate functional liver cells makes EBD cells potentially useful for cell therapy. |
| 学科主题 | Cell Biology ; Developmental Biology |
| 类目[WOS] | Cell Biology ; Developmental Biology |
| 关键词[WOS] | EMBRYONIC STEM-CELLS ; IN-VITRO DIFFERENTIATION ; HEPATOCYTE-LIKE CELLS ; CORD BLOOD ; MOUSE-LIVER ; TRANSPLANTATION ; FUSION ; SHEEP ; VIVO ; LINEAGE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000246707100002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1564]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chen, B,Shi, JJ,Zheng, JK,et al. Differentiation of liver cells from human primordial germ cell-derived progenitors[J]. DIFFERENTIATION,2007,75(5):350-359. |
| APA | Chen, B.,Shi, JJ.,Zheng, JK.,Chen, Y.,Wang, K.,...&Sheng, HZ.(2007).Differentiation of liver cells from human primordial germ cell-derived progenitors.DIFFERENTIATION,75(5),350-359. |
| MLA | Chen, B,et al."Differentiation of liver cells from human primordial germ cell-derived progenitors".DIFFERENTIATION 75.5(2007):350-359. |
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