Triptolide inhibits CCR5 expressed in synovial tissue of rat adjuvant-induced arthritis
文献类型：期刊论文
| 作者 | Wang, YF; Wei, DM; Lai, Z; Le, YP; Shen, JK |
| 刊名 | PHARMACOLOGICAL REPORTS
 |
| 出版日期 | 2007 |
| 卷号 | 59期号:6页码:795-799 |
| 关键词 | triptolide CCR5 adjuvant induced arthritis rheumatoid arthritis |
| 通讯作者 | Wei, DM (reprint author), Ningbo Univ, Sch Med, Dept Pathol, Ningbo 315211, Peoples R China.,weidengming@hotmail.com |
| 英文摘要 | Triptolide has been clinically used to treat patients with rheumatoid arthritis, in which chemokine receptors play an important role in immune and inflammatory responses. To investigate the effect of triptolide on CCR5, we used complete Freund's adjuvant to produce adjuvant-induced arthritis (AIA) in rats. Our data show that both CCR5 mRNA and protein levels in synovial tissue of rats with AIA are significantly higher than those in normal rats. Triptolide can significantly inhibit rat AIA-induced overexpression of CCR5 at both mRNA and protein levels. These results may contribute to better understanding of the therapeutic effects of triptolide in rheumatoid arthritis. |
| 学科主题 | Pharmacology & Pharmacy |
| 类目[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | CHEMOKINE RECEPTOR EXPRESSION ; COLLAGEN-INDUCED ARTHRITIS ; RHEUMATOID-ARTHRITIS ; LYMPHOCYTES ; ANTAGONIST ; JOINTS ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000252816100024 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1573]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, YF,Wei, DM,Lai, Z,et al. Triptolide inhibits CCR5 expressed in synovial tissue of rat adjuvant-induced arthritis[J]. PHARMACOLOGICAL REPORTS,2007,59(6):795-799. |
| APA | Wang, YF,Wei, DM,Lai, Z,Le, YP,&Shen, JK.(2007).Triptolide inhibits CCR5 expressed in synovial tissue of rat adjuvant-induced arthritis.PHARMACOLOGICAL REPORTS,59(6),795-799. |
| MLA | Wang, YF,et al."Triptolide inhibits CCR5 expressed in synovial tissue of rat adjuvant-induced arthritis".PHARMACOLOGICAL REPORTS 59.6(2007):795-799. |
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