Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype I
文献类型：期刊论文
| 作者 | Liu, GX; Cai, GQ; Cai, YQ; Sheng, ZJ; Jiang, J; Mei, ZT; Wang, ZG; Guo, LH; Fei, J |
| 刊名 | NEUROPSYCHOPHARMACOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 32期号:7页码:1531-1539 |
| 关键词 | GABA transporter I depression anxiety knockout mouse |
| 通讯作者 | Fei, JA (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Lab Mol Cell Biol, Inst Biochem & Cell Biol,Med Organism Res Ctr, 7 Bldg,319 Yue Yang Rd, Shanghai 200031, Peoples R China.,jfei@sibs.ac.cn |
| 英文摘要 | gamma-Aminobutyric acid (GABA) transporter subtype 1 (GAT1), which transports extracellular GABA into presynaptic neurons, plays an important regulatory role in the function of GABAergic systems. However, the contributions of the GAT1 in regulating mental status are not fully understood. In this paper, we observed the behavioral alterations of GAT1 knockout (GAT1(-/-)) mice using several depression- and anxiety-related models (eg, the forced-swimming test and the tail-suspension test for testing depression- related behaviors; the open-field test, the dark-light exploration test, the emergence test, and the elevated plus maze (EPM) test for anxiety-related behaviors). Here we found that GAT1(-/-) mice showed a lower level of depression- and anxiety-like behaviors in comparison to wild-type mice. Furthermore, GAT1(-/-) mice exhibited measurable insensitivity to selected antidepressants and anxiolytics such as fluoxetine, amitriptyline, buspirone, diazepam, and tiagabine in the tail- suspension test and/or the EPM test. Moreover, the basal level of corticosterone was found to be significantly lower in GAT1(-/-) mice. These results showed that the absence of GAT1 affects mental status through enhancing the GABAergic system, as well as modifying the serotonergic system and the hypothalamic-pituitary-adrenal (HPA) activity in mice. |
| 学科主题 | Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry |
| 类目[WOS] | Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
| 关键词[WOS] | ELEVATED PLUS-MAZE ; FORCED SWIMMING TEST ; TAIL SUSPENSION TEST ; ANIMAL-MODEL ; SEROTONIN TRANSPORTER ; RAT-BRAIN ; RECEPTOR ; ANTIDEPRESSANTS ; EXPRESSION ; RESPONSES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000247297500008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1584]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, GX,Cai, GQ,Cai, YQ,et al. Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype I[J]. NEUROPSYCHOPHARMACOLOGY,2007,32(7):1531-1539. |
| APA | Liu, GX.,Cai, GQ.,Cai, YQ.,Sheng, ZJ.,Jiang, J.,...&Fei, J.(2007).Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype I.NEUROPSYCHOPHARMACOLOGY,32(7),1531-1539. |
| MLA | Liu, GX,et al."Reduced anxiety and depression-like behaviors in mice lacking GABA transporter subtype I".NEUROPSYCHOPHARMACOLOGY 32.7(2007):1531-1539. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。