P-selectin primes leukocyte integrin activation during inflammation
文献类型：期刊论文
| 作者 | Wang, HB; Wang, JT; Zhang, L; Geng, ZH; Xu, WL; Xu, T; Huo, YQ; Zhu, XL; Plow, EF; Chen, M |
| 刊名 | NATURE IMMUNOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 8期号:8页码:882-892 |
| 通讯作者 | Geng, JG (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol,Lab Mol Cell Biol, Shanghai 200031, Peoples R China.,chenm@sibs.ac.cn ; genglab@gmail.com |
| 英文摘要 | Selectins mediate leukocyte rolling and prime leukocytes for integrin-mediated leukocyte adhesion. However, neither the in vivo importance of nor the signaling pathway by which selectin-mediated integrin activation occurs has been determined. We report here that P-selectin-deficient mice manifested impaired leukocyte adhesion, which was 'rescued' by soluble P-selectin. Mechanistically, the cytoplasmic domain of P-selectin glycoprotein ligand 1 formed a constitutive complex with Nef-associated factor 1. After binding of P-selectin, Src kinases phosphorylated Nef-associated factor 1, which recruited the phosphoinositide-3-OH kinase p85-p110 delta heterodimer and resulted in activation of leukocyte integrins. Inhibition of this signal-transduction pathway diminished the adhesion of leukocytes to capillary venules and suppressed peritoneal infiltration of leukocytes. Our data demonstrate the functional importance of this newly identified signaling pathway mediated by P-selectin glycoprotein ligand 1. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | ALPHA-INDUCED INFLAMMATION ; GLYCOPROTEIN LIGAND 1 ; FIRM ADHESION ; MUTANT MICE ; SRC KINASES ; NEUTROPHILS ; CELL ; BINDING ; EXPRESSION ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248169400016 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1590]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, HB,Wang, JT,Zhang, L,et al. P-selectin primes leukocyte integrin activation during inflammation[J]. NATURE IMMUNOLOGY,2007,8(8):882-892. |
| APA | Wang, HB.,Wang, JT.,Zhang, L.,Geng, ZH.,Xu, WL.,...&Geng, JG.(2007).P-selectin primes leukocyte integrin activation during inflammation.NATURE IMMUNOLOGY,8(8),882-892. |
| MLA | Wang, HB,et al."P-selectin primes leukocyte integrin activation during inflammation".NATURE IMMUNOLOGY 8.8(2007):882-892. |
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