Morphine and heroin differentially modulate in vivo hippocampal LTP in opiate-dependent rat
文献类型：期刊论文
| 作者 | Bao, GB; Kang, L; Li, HH; Li, YT; Pu, L; Xia, P; Ma, L; Pei, G |
| 刊名 | NEUROPSYCHOPHARMACOLOGY
 |
| 出版日期 | 2007 |
| 卷号 | 32期号:8页码:1738-1749 |
| 关键词 | hippocampal LTP morphine heroin PKA opioid receptor opiate antagonist |
| 通讯作者 | Pei, G (reprint author), Chinese Acad Sci, Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue-Yang Rd, Shanghai 200031, Peoples R China.,gpei@sibs.ac.cn |
| 英文摘要 | Addictive drugs have been shown to severely influence many neuronal functions, which are considered as the underlying mechanisms for physiological and psychological dependences. We previously showed that in vivo LTP in rat hippocampal CA1 region is significantly reduced during withdrawal following chronic opiates treatment, and the reduced LTP can be restored by re-exposure of animals to corresponding drugs. Here, we further demonstrated that during opiates withdrawal, the re-exposure of morphine either systemically (subcutaneously) or locally (intracerebroventricularly) could restore the reduced LTP in heroin-dependent rats, but heroin could not restore the reduced LTP, in morphine-dependent rats, indicating differential modulations of hippocampal functions by those two opiates. In contrast, DAMGO, a mu-opioid receptor (MOR) agonist, could restore the reduced LTP, and CTOP, a MOR antagonist, could block the restoration in rats dependent on both opiates, showing that MOR is functional under such conditions. However, the upregulation of hippocampal PKA activity during morphine withdrawal could be suppressed by re-exposure of morphine but not that of heroin, suggesting a likely underlying mechanism of the differential modulation of LTP by two opiates. Taken together, our study clearly demonstrates that chronic abuse of opiates inevitably leads to severe alteration of hippocampal LTP, and reveals the interesting differences between morphine and heroin in their effects on the differential modulation of hippocampal synaptic plasticity. |
| 学科主题 | Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry |
| 类目[WOS] | Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
| 关键词[WOS] | LONG-TERM POTENTIATION ; OPIOID-RECEPTOR GENE ; CONDITIONED PLACE PREFERENCE ; RHESUS-MONKEYS ; PROTEIN-KINASE ; MORPHINE-6-BETA-GLUCURONIDE ANALGESIA ; PHOSPHORYLATION SITES ; SYNAPTIC PLASTICITY ; DORSAL HIPPOCAMPUS ; DRUG-ADDICTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248146900010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1591]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Bao, GB,Kang, L,Li, HH,et al. Morphine and heroin differentially modulate in vivo hippocampal LTP in opiate-dependent rat[J]. NEUROPSYCHOPHARMACOLOGY,2007,32(8):1738-1749. |
| APA | Bao, GB.,Kang, L.,Li, HH.,Li, YT.,Pu, L.,...&Pei, G.(2007).Morphine and heroin differentially modulate in vivo hippocampal LTP in opiate-dependent rat.NEUROPSYCHOPHARMACOLOGY,32(8),1738-1749. |
| MLA | Bao, GB,et al."Morphine and heroin differentially modulate in vivo hippocampal LTP in opiate-dependent rat".NEUROPSYCHOPHARMACOLOGY 32.8(2007):1738-1749. |
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