RNAi machinery
文献类型：期刊论文
| 作者 | Liu, MF; Jiang, S; Wang, ED |
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2007 |
| 卷号 | 34期号:10页码:1012-1017 |
| 关键词 | RNAi RNAi machinery Argonaute PIWI small RNA |
| 通讯作者 | Liu, MF (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,mfliu@sibs.ac.cn |
| 英文摘要 | The small noncoding RNAs, unlike the canonical regulatory protein factors, regulate messenger RNA stability, protein synthesis, chromatin organization and genome structure by RNA interference. Owing to its apparent overarching control and ease of manipulation, RNAi has been extensively used as a tool for investigating gene function and is being exploited as a potential therapeutic tool through silencing. Small RNAs effect gene silencing through RNAi machinery - the effector complexes of RNAi, which contain multiple protein components. Here, a few impressive progresses in understanding the role of the key proteins in RNAi machinery through studies of their structure and function were reviewed. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | ARGONAUTE2 PAZ DOMAIN ; CELL SELF-RENEWAL ; CRYSTAL-STRUCTURE ; C-ELEGANS ; CAENORHABDITIS-ELEGANS ; EFFECTOR COMPLEXES ; SLICER ACTIVITY ; PIWI ; PROTEIN ; GENE |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000250492600001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1603]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, MF,Jiang, S,Wang, ED. RNAi machinery[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2007,34(10):1012-1017. |
| APA | Liu, MF,Jiang, S,&Wang, ED.(2007).RNAi machinery.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,34(10),1012-1017. |
| MLA | Liu, MF,et al."RNAi machinery".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 34.10(2007):1012-1017. |
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