Existence of an endogenous glutamate and aspartate transporter in Chinese hamster ovary cells
文献类型：期刊论文
| 作者 | Ji, XH; Jin, YH; Chen, YY; Li, CY; Guo, LH |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2007 |
| 卷号 | 39期号:11页码:851-856 |
| 关键词 | GLAST CHO cell glutamate transporter |
| 通讯作者 | Guo, LH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,mhzhang@sunm.shcnc.ac.cn |
| 英文摘要 | Chinese hamster ovary cells show endogenous high-affinity Na+-dependent glutamate transport activity. This transport activity is kinetically similar to a glutamate transporter family strategically expressed in the central nervous system and is pharmacologically unlike glutamate transporter-1 or excitatory amino acid carrier 1. The cDNA of a glutamate/aspartate transporter (GLAST)-like transporter was obtained and analyzed. The deduced amino acid sequence showed high similarity to human, mouse, and rat GLAST. We concluded that a GLAST-like glutamate transporter exists in Chinese hamster ovary cells that might confer the endogenous high-affinity Na+-dependent glutamate transport activity evident in these cells. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | AMINO-ACID TRANSPORTER ; HIGH-AFFINITY ; FUNCTIONAL-CHARACTERIZATION ; RAT-BRAIN ; EXPRESSION ; GLAST-1 ; CLONING |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000251184600005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1607]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Ji, XH,Jin, YH,Chen, YY,et al. Existence of an endogenous glutamate and aspartate transporter in Chinese hamster ovary cells[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2007,39(11):851-856. |
| APA | Ji, XH,Jin, YH,Chen, YY,Li, CY,&Guo, LH.(2007).Existence of an endogenous glutamate and aspartate transporter in Chinese hamster ovary cells.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,39(11),851-856. |
| MLA | Ji, XH,et al."Existence of an endogenous glutamate and aspartate transporter in Chinese hamster ovary cells".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 39.11(2007):851-856. |
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