Regulation and pharmacokinetics of inducible recombinant TRAIL expression
文献类型：期刊论文
| 作者 | Dong, AW; Hu, J; Zhao, LL; Xu, HL; Liu, XY |
| 刊名 | CANCER BIOLOGY & THERAPY
 |
| 出版日期 | 2007 |
| 卷号 | 6期号:12页码:1978-1985 |
| 关键词 | recombinant TRAIL RU 486 regulatory system expression kinetics cancer gene therapy |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,xyliu@sibs.ac.cn |
| 英文摘要 | TRAIL is a potent antitumor agent, but its potential toxicity to normal human tissues limits its clinical applications in future. Therapy of human tumors might benefit from the use of vectors enabling tight control of TRAIL expression in vivo. To this aim, we constructed an adenoviral vector carrying the RU486-dependent gene switch system for the regulable expression of recombinant TRAIL. Only was apoptotic recombinant TRAIL expressed and cytotoxicity observed upon binding of RU 486 to the inducible promoter. Expression levels and kinetics of recombinant TRAIL expression could be achieved by modulating the concentration of the inducer. As a broad implication, our data provide an alternative approach to circumvent the potential toxicity of TRAIL in future human trials and this system may be utilized to treat human cancer using a long-term expression vector. |
| 学科主题 | Oncology |
| 类目[WOS] | Oncology |
| 关键词[WOS] | PRIMARY HUMAN HEPATOCYTES ; GENE-TRANSFER ; TRIMERIC TRAIL ; TUMOR-GROWTH ; IN-VIVO ; APOPTOSIS ; LIGAND ; THERAPY ; CELLS ; SYSTEM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000253944900029 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1620]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Dong, AW,Hu, J,Zhao, LL,et al. Regulation and pharmacokinetics of inducible recombinant TRAIL expression[J]. CANCER BIOLOGY & THERAPY,2007,6(12):1978-1985. |
| APA | Dong, AW,Hu, J,Zhao, LL,Xu, HL,&Liu, XY.(2007).Regulation and pharmacokinetics of inducible recombinant TRAIL expression.CANCER BIOLOGY & THERAPY,6(12),1978-1985. |
| MLA | Dong, AW,et al."Regulation and pharmacokinetics of inducible recombinant TRAIL expression".CANCER BIOLOGY & THERAPY 6.12(2007):1978-1985. |
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