Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells
文献类型：期刊论文
| 作者 | Liu, HX; Huang, GR; Zhang, HM; Wu, JR; Yao, ZJ |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2007 |
| 卷号 | 17期号:12页码:3426-3430 |
| 关键词 | annonaceous acetogenin mimicry anticancer fluorescent labeling cytotoxicity |
| 通讯作者 | Wu, JR (reprint author), Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, 354 Fenglin Rd, Shanghai 200032, Peoples R China.,yaoz@mail.sioc.ac.cn |
| 英文摘要 | Annonaceous acetogenins are a large class of naturally occurring polyketides exhibiting potent anticancer activities. Based on our previous discovery of AA005, a multi-ether mimic of natural acetogenins having potent antitumor activities and significant selectivity between normal cells and cancer cells, a new series of mimics containing a terminal lactam were designed, synthesized and evaluated. Bioactivity study against cancer cells shows that the N-methylated lactam-containing compounds 3, 4, and 5 exhibit comparable potencies to that of AA005, as well as the similar selectivity to cancer cells. Hydrocarbon-length effects of N-alkyl were further explored through synthesizing derivatives 24-26, and application of this derivation protocol to the fluorescent labeling was also investigated. (c) 2007 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Chemistry |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Organic |
| 关键词[WOS] | REMARKABLE SELECTIVE CYTOTOXICITY ; ANALOGS ; INHIBITORS ; ASIMICIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000247496200036 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1621]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, HX,Huang, GR,Zhang, HM,et al. Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(12):3426-3430. |
| APA | Liu, HX,Huang, GR,Zhang, HM,Wu, JR,&Yao, ZJ.(2007).Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(12),3426-3430. |
| MLA | Liu, HX,et al."Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.12(2007):3426-3430. |
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