Targeting strategies for adeno-associated viral vector
文献类型：期刊论文
| 作者 | Wang, YG; Huang, F; Cai, R; Qian, C; Liu, XY |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2007 |
| 卷号 | 52期号:12页码:1590-1599 |
| 关键词 | AAV targeting gene therapy |
| 通讯作者 | Qian, C (reprint author), Zhejiang Sci Tech Univ, Coll Life Sci, Xinyuan Inst Med & Biotechnol, Hangzhou 310018, Peoples R China.,cqian3184@yahoo.com.cn ; xyliu@sibs.ac.cn |
| 英文摘要 | Adeno-associated virus (AAV) has rapidly become a promising gene delivery vector for its excellent advantages of low pathogenicity and long-term gene expression over other viral vectors for human gene therapy. However, the disadvantage of AAV for clinical gene therapy is the broad host range and the lack of tissue or cell specificity, which makes AAVs relatively inefficient gene delivery to target cells and short of safety. Therefore, it is required to improve the targeting capability of recombinant adeno-associated virus (rAAV) for successful gene therapy. At present, the successful identification of various-serotype AAVs and the improvement of rAAV production technology make it feasible to explore new applications of rAAV vector in clinical gene therapy trials. Moreover, the current development in targeting strategy has brought a bright prospect to rAAV vectors. Many studies have demonstrated that targeting gene therapy based on rAAV vectors could be achieved through transcription targeted, conjugate targeted, receptor targeted, gene recombinant targeted strategies, etc. This report gives a comprehensive review of the recent developments of targeting strategies for rAAV vectors. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | MEDIATED GENE-TRANSFER ; CENTRAL-NERVOUS-SYSTEM ; VIRUS VECTORS ; TRANSGENE EXPRESSION ; IN-VIVO ; HEMOPHILIA-B ; SUSTAINED CORRECTION ; TELOMERASE ACTIVITY ; THERAPY VECTORS ; SKELETAL-MUSCLE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000247578400002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1622]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, YG,Huang, F,Cai, R,et al. Targeting strategies for adeno-associated viral vector[J]. CHINESE SCIENCE BULLETIN,2007,52(12):1590-1599. |
| APA | Wang, YG,Huang, F,Cai, R,Qian, C,&Liu, XY.(2007).Targeting strategies for adeno-associated viral vector.CHINESE SCIENCE BULLETIN,52(12),1590-1599. |
| MLA | Wang, YG,et al."Targeting strategies for adeno-associated viral vector".CHINESE SCIENCE BULLETIN 52.12(2007):1590-1599. |
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