Cyclin G associated kinase interacts with interleukin 12 receptor beta 2 and suppresses interleukin 12 induced IFN-gamma production
文献类型：期刊论文
| 作者 | Lin, Y; Tang, YJ; Zong, HL; Gu, JX; Deng, WW; Wang, C; Sun, B |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2007 |
| 卷号 | 581期号:26页码:5151-5157 |
| 关键词 | cyclin G associated kinase interleukin 12 receptor beta 2 T cell activation IFN-gamma induction |
| 通讯作者 | Wang, C (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Lab Mol Immunol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,cwang01@sibs.ac.cn |
| 英文摘要 | Interleukin 12 receptor beta 1 (IL-12R beta 1) and beta 2 (IL-12R beta 2) constitute the functional and high-affinity receptor complex for interleukin 12 (IL-12) and mediate important functions in activated T cells. In this study, we identified cyclin G associated kinase (GAK) as a new IL-12R beta 2-interacting protein using yeast two-hybrid system and confirmed it by coimmunoprecipitation assays. Overexpression of GAK in activated T cells suppresses IL-12 induced IFN-gamma production but has no detectable effects on its proliferation, whereas knockdown of GAK by RNA interference (RNAi) increases IFN-gamma production. These results suggest that GAK associates with IL-12R beta 2 and may play a role in regulating IL-12 signaling. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | STAT4 SERINE PHOSPHORYLATION ; CLATHRIN-COATED VESICLES ; IL-12 RECEPTOR ; TYROSINE PHOSPHORYLATION ; SIGNAL TRANSDUCER ; CELLS ; ACTIVATION ; PROLIFERATION ; CYTOKINE ; SUBUNIT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000250802700025 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1633]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Lin, Y,Tang, YJ,Zong, HL,et al. Cyclin G associated kinase interacts with interleukin 12 receptor beta 2 and suppresses interleukin 12 induced IFN-gamma production[J]. FEBS LETTERS,2007,581(26):5151-5157. |
| APA | Lin, Y.,Tang, YJ.,Zong, HL.,Gu, JX.,Deng, WW.,...&Sun, B.(2007).Cyclin G associated kinase interacts with interleukin 12 receptor beta 2 and suppresses interleukin 12 induced IFN-gamma production.FEBS LETTERS,581(26),5151-5157. |
| MLA | Lin, Y,et al."Cyclin G associated kinase interacts with interleukin 12 receptor beta 2 and suppresses interleukin 12 induced IFN-gamma production".FEBS LETTERS 581.26(2007):5151-5157. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。