Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells (Retracted article. See vol. 30, pg. 2798, 2011)
文献类型：期刊论文
| 作者 | Jie, X; Lang, C; Jian, Q; Chaoqun, L; Dehua, Y; Yu, S; Yanping, J; Luokun, X; Qiuping, Z; Hui, W |
| 刊名 | ONCOGENE
 |
| 出版日期 | 2007 |
| 卷号 | 26期号:39页码:5741-5751 |
| 关键词 | hepatocellular carcinoma androgen androgen receptor PEG10 apoptosis |
| 通讯作者 | Jinquan, T (reprint author), Wuhan Univ, Sch Med, Dept Immunol, Dong Hu Rd 115, Wuhan 430071, Hubei, Peoples R China.,jinquan_tan@hotmail.com |
| 英文摘要 | The molecular mechanism of striking higher prevalence of hepatocellular carcinoma (HCC) in male subjects has not yet been fully elucidated. Here, we report that androgen receptor (AR) is differentially expressed in different HCC cell lines. AR agonist dihydrotestosterone (DHT) enhances HCC cell growth and apoptotic resistance. Antagonist flutamide (FLU) blocks the effects of DHT on the HCC cell lines. Paternally expressed gene 10 (PEGI10) is expressed in HCC cell lines at substantial high level. Using small interfering RNAs against AR and PEG10 in AR- and PEG10-expressing BEL-7404 hepatoma cells and HuH7 hepatoma cells (HuH7) cells, and AR-transfection technique in AR-lacking and PEG10-expressing HepG2 cells, we have confirmed that through upregulation and activation of PEG10, DHT enhances HCC cell growth and apoptotic resistance. We have further demonstrated that DHT upregulates expression of human telomerase reverse transcriptase (hTERT) in HCC cell lines in a PEG10-dependent manner. Moreover, AR directly interacts in vivo with androgen-responsive elements in the regions of promoter and exon 2 of PEG10 gene in HCC cell lines. DHT promotes the hepatoma formation in viro nude mice through PEG10 activation. AR antagonists (FLU and valproate) inhibit the hepatoma formation. These findings suggest that PEG10 plays an essential role in hepatocarcinogenesis. The PEG10 inhibition can be a novel approach for therapy of HCC. |
| 学科主题 | Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| 类目[WOS] | Biochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity |
| 关键词[WOS] | HEPATOCELLULAR-CARCINOMA ; IMPRINTED GENE ; APOPTOSIS ; EXPRESSION ; INTERACTS ; RECEPTOR ; PROTEIN ; RETROTRANSPOSON |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248885100006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1635]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Jie, X,Lang, C,Jian, Q,et al. Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells (Retracted article. See vol. 30, pg. 2798, 2011)[J]. ONCOGENE,2007,26(39):5741-5751. |
| APA | Jie, X.,Lang, C.,Jian, Q.,Chaoqun, L.,Dehua, Y.,...&Jinquan, T.(2007).Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells (Retracted article. See vol. 30, pg. 2798, 2011).ONCOGENE,26(39),5741-5751. |
| MLA | Jie, X,et al."Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells (Retracted article. See vol. 30, pg. 2798, 2011)".ONCOGENE 26.39(2007):5741-5751. |
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