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JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer
文献类型：期刊论文
| 作者 | Xiang, Y; Zhu, Z; Han, G; Ye, X; Xu, B; Peng, Z; Ma, Y; Yu, Y; Lin, H; Chen, AP |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2007 |
| 卷号 | 104期号:49页码:19226-19231 |
| 关键词 | demethylation methylation transcription JmjC domain |
| 通讯作者 | Chen, CD (reprint author), Inst Biochem & Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,cdchen@sibs.ac.cn |
| 英文摘要 | Histone methylation is a dynamic process that participates in a diverse array of cellular processes and has been found to associate with cancer. Recently, several histone demethylases have been identified that catalyze the removal of methylation from histone H3 lysine residues. Through bioinformatic and biochemical analysis, we identified JARID1B as a H3K4 demethylase. Overexpression of JARID1B resulted in loss of tri-, di-, and monomethyl H3K4 but did not affect other histone lysine methylations. In vitro biochemical experiments demonstrated that JARID1B directly catalyzes the demethylation. The enzymatic activity requires the JmjC domain and uses Fe(II) and alpha-ketoglutarate as cofactors. Furthermore, we found that JARID1B is up-regulated in prostate cancer tissues, compared with benign prostate samples. We also demonstrated that JARID1B associates with androgen receptor and regulates its transcriptional activity. Thus, we identified JARID1B as a demethylase capable of removing three methyl groups from histone H3 lysine 4 and up-regulated in prostate cancer. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | ANDROGEN-RECEPTOR ; BREAST-CANCER ; JMJD2 FAMILY ; H3 LYSINE-9 ; PHD FINGER ; METHYLATION ; TRANSCRIPTION ; BINDING ; GENE ; CHROMATIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000251525800014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1636]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xiang, Y,Zhu, Z,Han, G,et al. JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2007,104(49):19226-19231. |
| APA | Xiang, Y.,Zhu, Z.,Han, G.,Ye, X.,Xu, B.,...&Chen, CD.(2007).JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,104(49),19226-19231. |
| MLA | Xiang, Y,et al."JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104.49(2007):19226-19231. |
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