The role of Paraxial Protocadherin in Xenopus otic placode development
文献类型：期刊论文
| 作者 | Hu, RY; Xu, P; Chen, YL; Lou, X; Ding, XY |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2006 |
| 卷号 | 345期号:1页码:239-247 |
| 关键词 | PAPC otic placode otic vesicle inner ear Sox9 Tbx2 Xenopas laevis |
| 通讯作者 | Ding, XY (reprint author), Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Mol Cell Biol Lab,Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xyding@sunm.shcnc.ac.cn |
| 英文摘要 | Vertebrate inner ear develops from its rudiment, otic placode, which later forms otic vesicle and gives rise to tissues comprising the 14 entire inner ear. Although several signaling molecules have been identified as candidates responsible for inner ear specification and patterning, many details remain elusive. Here, we report that Paraxial Protocadherin (PAPC) is required for otic vesicle formation in Xenopus embryos. PAPC is expressed strictly in presumptive otic placode and later in otic vesicle during inner ear morphogenesis. Knockdown of PAPC by dominant-negative PAPC results in the failure of otic vesicle formation and the loss of early inner ear markers Sox9 and Tbx2, suggesting the requirement of PAPC in the early stage of otic vesicle development. However, PAPC alone is not sufficient to induce otic placode formation. (c) 2006 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | INNER-EAR DEVELOPMENT ; SONIC HEDGEHOG ; SPECIFICATION ; MOUSE ; MESODERM ; SOMITOGENESIS ; EXPRESSION ; INDUCTION ; INTERACTS ; LAEVIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000237877700034 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1645]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hu, RY,Xu, P,Chen, YL,et al. The role of Paraxial Protocadherin in Xenopus otic placode development[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,345(1):239-247. |
| APA | Hu, RY,Xu, P,Chen, YL,Lou, X,&Ding, XY.(2006).The role of Paraxial Protocadherin in Xenopus otic placode development.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,345(1),239-247. |
| MLA | Hu, RY,et al."The role of Paraxial Protocadherin in Xenopus otic placode development".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 345.1(2006):239-247. |
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