Analysis of tissue-specific region in sericin 1 gene promoter of Bombyx mori
文献类型：期刊论文
| 作者 | Liu, Y; Yu, L; Guo, XY; Guo, TQ; Wang, SP; Lu, CD |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2006 |
| 卷号 | 342期号:1页码:273-279 |
| 关键词 | Bombyx mori Sericin 1 promoter tissue-specificity ectopic expression Autographa californica multiple nuclear polyhedrosis virus |
| 通讯作者 | Lu, CD (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,cdlu@sibs.ac.cn |
| 英文摘要 | The gene encoding sericin 1 (Set1) of silkworm (Bombyx mori) is specifically expressed in the middle silk gland cells. To identify element involved in this transcription-dependent spatial restriction, truncation of the 5' terminal from the sericin 1 (Ser1) promoter is studied in vivo. A 209 by DNA sequence upstream of the transcriptional start site (-586 to -378) is found to be responsible for promoting tissue-specific transcription. Analysis of this 209 by region by overlapping deletion studies showed that a 25 by region (-500 to -476) suppresses the ectopic expression of the Ser1 promoter. An unknown factor abundant in fat body nuclear extracts is shown to bind to this 25 by fragment. These results suggest that this 25 by region and the unknown factor are necessary for determining the tissue-specificity of the Set1 promoter. (c) 2006 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | SILK GLAND ; BINDING-SITES ; CAENORHABDITIS-ELEGANS ; POU DOMAIN ; EXPRESSION ; SYSTEM ; TRANSCRIPTION ; CONTAINS ; UPSTREAM ; DELIVERY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000235793800037 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1647]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Y,Yu, L,Guo, XY,et al. Analysis of tissue-specific region in sericin 1 gene promoter of Bombyx mori[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,342(1):273-279. |
| APA | Liu, Y,Yu, L,Guo, XY,Guo, TQ,Wang, SP,&Lu, CD.(2006).Analysis of tissue-specific region in sericin 1 gene promoter of Bombyx mori.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,342(1),273-279. |
| MLA | Liu, Y,et al."Analysis of tissue-specific region in sericin 1 gene promoter of Bombyx mori".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 342.1(2006):273-279. |
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