Targeting gene-virotherapy of cancer (Retracted Article. See vol 16, pg 740, 2006)
文献类型：期刊论文
| 作者 | Liu, XY; Gu, JF |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2006 |
| 卷号 | 16期号:1页码:25-30 |
| 关键词 | targeting therapy cancer therapy gene-virotherapy |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,xyliu@sibs.ac.cn |
| 英文摘要 | Our purpose is to completely elimination of xenograft tumor in animal tumor model in order to work out a protocal for the cure of patient. Gene therapy and viral therapy for cancer have got some therapeutic effects, but both have no great breakthrough. Therefore, we worked out a new strategy called Targeting Gene-Virotherapy of Cancer which is a combination of the advantage of gene therapy and virotherapy. This new strategy has stronger antitumor effect than either of them alone. A tumor specific replicative adenovirus vector ZD55 (EIB 55KD deleted Adv.) which is similar to ONYX-015 in targeting fuction but significant different in construction was produced and various single therapeutic gene was inserted into ZD55. Now such a conception as Targeting Gene-Virotherapy of Cancer was raised and systemically studied before, although there are some works on ONYX-015-tk, -cd or cd/-tk etc. separately. The antitumor effect of ZD55-Gene (for example IL-24 gene) is much better than ZD55 (virotherapy) alone and hundred fold high than that of Ad-IL-24 (gene therapy) alone. ZD55-IL-24 was in preclinal Studying in the ZD55-IL-24 therapy, completely elimination of tumor mass was occurred in some mice but not in all mice, that means one gene was not effictive enough to eliminate all the tumor mass in all mice. Therefore two genes with compensative or synergetic effect were inserted into ZD55 sepearately and used in combinction. This strategy was called Targeting Dual Gene-Virotherapy of Cancer (with PCT patent). Then much better results were obtained and all the xenograft tumor masses were completely eliminated in all mice, if two suitable genes were chosen. On the basis of the initiation of two gene results, it was thought about that using two tumors promoter to control the virus vector will be better for the targeting effect and the safty of the drugs. Then double tumor controlled virus vector harboring two genes for cancer therapy was worked out. Better results have been obtained and another patent has been applied. This antitumor strategy could be used to kill all the tumor cells completely in all mice with minimum damage to normal cells. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | ANTITUMOR-ACTIVITY ; CELLS ; APOPTOSIS ; POTENT ; TRAIL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000236961100005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1653]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, XY,Gu, JF. Targeting gene-virotherapy of cancer (Retracted Article. See vol 16, pg 740, 2006)[J]. CELL RESEARCH,2006,16(1):25-30. |
| APA | Liu, XY,&Gu, JF.(2006).Targeting gene-virotherapy of cancer (Retracted Article. See vol 16, pg 740, 2006).CELL RESEARCH,16(1),25-30. |
| MLA | Liu, XY,et al."Targeting gene-virotherapy of cancer (Retracted Article. See vol 16, pg 740, 2006)".CELL RESEARCH 16.1(2006):25-30. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。