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Neuroprotective effect of a20 on TNF-induced postischemic apoptosis

文献类型：期刊论文

作者Yu, LY; Miao, HS; Hou, YN; Zhang, B; Guo, LH
刊名NEUROCHEMICAL RESEARCH
出版日期2006
卷号31期号:1页码:21-32
关键词A20 gene TNF-alpha apoptosis focal cerebral ischemia
通讯作者Guo, LH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Room 901,Cell Biol Bldg,320 Yueyang Rd, Shanghai 200031, Peoples R China.,lhguo@sunm.shcnc.ac.cn
英文摘要Focal cerebral ischemia causes apoptosis in neural cells during the postischemia period. TNF is critically involved in such neuronal apoptosis mediated by caspase pathways. A20 can inhibit TNF-induced apoptosis in many cell types. However, little work has been carried out in central nervous system. In the present study, gene transfer of A20 resulted in reduction of infarct volume and improvement of neurological deficit in ischemia rats. Results of flow cytometry, TUNEL and DNA fragmentation assay all indicated A20 could inhibit TNF-induced apoptosis both in primary rat hippocampal neurons and SH-SY5Y cells. Moreover, we found A20 targeted the TNF apoptotic pathway by inhibiting proteolytic cleavage of caspase 8 and 3 in SH-SY5Y cells. These data demonstrated A20 could effectively protect neurons from postischemic apoptosis and may function partly on death receptor caspase pathway. Gene transfer of A20 may be a promising approach to gene therapy for cerebral ischemia in the future.
学科主题Biochemistry & Molecular Biology; Neurosciences & Neurology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
关键词[WOS]TUMOR-NECROSIS-FACTOR ; FOCAL CEREBRAL-ISCHEMIA ; ZINC-FINGER PROTEIN ; HEPATOCYTE GROWTH-FACTOR ; HUMAN ENDOTHELIAL-CELLS ; DELAYED NEURONAL DEATH ; FACTOR-ALPHA ; ARTERY OCCLUSION ; IN-VIVO ; FOREBRAIN ISCHEMIA
收录类别SCI
语种英语
WOS记录号WOS:000235308600003
版本出版稿
源URL[http://202.127.25.143/handle/331003/1658]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714		 Yu, LY,Miao, HS,Hou, YN,et al. Neuroprotective effect of a20 on TNF-induced postischemic apoptosis[J]. NEUROCHEMICAL RESEARCH,2006,31(1):21-32.
APA Yu, LY,Miao, HS,Hou, YN,Zhang, B,&Guo, LH.(2006).Neuroprotective effect of a20 on TNF-induced postischemic apoptosis.NEUROCHEMICAL RESEARCH,31(1),21-32.
MLA Yu, LY,et al."Neuroprotective effect of a20 on TNF-induced postischemic apoptosis".NEUROCHEMICAL RESEARCH 31.1(2006):21-32.

入库方式： OAI收割

来源：上海生物化学与细胞生物学研究所

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