Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal
文献类型：期刊论文
| 作者 | Sun, N; Li, Y; Tian, S; Lei, Y; Zheng, J; Yang, J; Sui, N; Xu, L; Pei, G; Wilson, FAW |
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2006 |
| 卷号 | 138期号:1页码:77-82 |
| 关键词 | conditioned place preference manganese-enhanced MRI gamma-band EEG drug craving |
| 通讯作者 | Lei, H (reprint author), Chinese Acad Sci, Kunming Inst Zool, Lab Primate Cognit Neurosci, Kunming 650223, Peoples R China.,leihao@wipm.ac.cn ; xhu@cns.bcm.tmc.edu |
| 英文摘要 | The orbitofrontal cortex is involved in the reinforcing effects of drugs of abuse. However, how the dynamic activity in OFC changes during opiate administration and withdrawal period has not been investigated. We first tested the effects of opiates and drug craving with the conditioned place preference paradigm, using manganese-enhanced magnetic resonance imaging and traditional electroencephalograph recording techniques in rats. T1-weighted 2D MRI (4.7 T) was used after unilateral injection of MnCl2 (200 nL, 80 mM) into the right orbitofrontal cortex. The manganese-enhanced magnetic resonance imaging data suggested that the OFC activity decreased during the opiate administration period but recovered increasingly during the withdrawal period. Also, we found decreases and increases in gamma-band (20-100 Hz) activity during the opiate administration and withdrawal period, respectively. Our results showed that orbitofrontal cortex activity decreased during morphine administration and then went up progressively over several days during withdrawal. The time course of the recovery of orbitofrontal activity from inhibition during the withdrawal period may be related to the experience of drug craving. (c) 2005 Published by Elsevier Ltd on behalf of IBRO. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | CONDITIONED PLACE PREFERENCE ; MANGANESE-ENHANCED MRI ; MAGNETIC-RESONANCE ; MORPHINE ; ACTIVATION ; DEPENDENCE ; ADDICTION ; SYSTEM ; BRAIN ; INHIBITION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000235947400009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1659]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Sun, N,Li, Y,Tian, S,et al. Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal[J]. NEUROSCIENCE,2006,138(1):77-82. |
| APA | Sun, N.,Li, Y.,Tian, S.,Lei, Y.,Zheng, J.,...&Hu, X.(2006).Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal.NEUROSCIENCE,138(1),77-82. |
| MLA | Sun, N,et al."Dynamic changes in orbitofrontal neuronal activity in rats during opiate administration and withdrawal".NEUROSCIENCE 138.1(2006):77-82. |
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