Mice with genetically altered GABA transporter subtype 1 (GAT1) expression show altered behavioral responses to ethanol
文献类型：期刊论文
| 作者 | Cai, YQ; Cai, GQ; Liu, GX; Cai, Q; Shi, JH; Shi, J; Ma, SK; Sun, X; Sheng, ZJ; Mei, ZT |
| 刊名 | JOURNAL OF NEUROSCIENCE RESEARCH
 |
| 出版日期 | 2006 |
| 卷号 | 84期号:2页码:255-267 |
| 关键词 | GABA transporter knockout ethanol behavioral reward |
| 通讯作者 | Fei, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Model Organism Res Ctr, Inst Biochem & Cell Biol,Lab Mol Cell Biol, 7 Bldg,319 Yue Yang Rd, Shanghai 200031, Peoples R China.,jfei@sibs.ac.cn |
| 英文摘要 | It is widely accepted that the GABAergic system plays an important role in the action of ethanol in vivo. GABA transporter subtype 1 (GAT1) constructs high affinity reuptake sites in the CNS and regulates GABAergic transmissions. In this study, mice lacking the GAT1 were developed by homologous recombination. Both hetero- and homozygous GAT1 mutant mice were tested for ethanol, saccharin or quinine consumption, ethanol-conditioned place preference, ethanol-conditioned taste aversion, ethanol-simulated motor activity and ethanol-induced sedation/hypnosis. The GAT(-/-) mice showed decreased ethanol aversion and ethanol reward, and insensitivity to both the sedative/hypnotic and the motor stimulant effects of ethanol, along with increased avoidance of quinine preference and consumption. GAT1(+/-) mice showed significantly increased consumption of ethanol and saccharin, however, enhanced the rewarding and preference effect of ethanol, increased avoidance of quinine, and higher sensitivity to the motor stimulant effect of ethanol. These results demonstrate that GAT1, perhaps in a bi-directional way, modulates some behavioral effects of ethanol. The GAT1 mutant mice provided us a very useful model to investigate the mechanisms of ethanol action in vivo. (c) 2006 Wiley-Liss, Inc. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 关键词[WOS] | RAT-BRAIN ; TRANSGENIC MICE ; MUTANT MICE ; I LEADS ; TIAGABINE ; ALCOHOL ; OVEREXPRESSION ; RECEPTORS ; LOCALIZATION ; TRAFFICKING |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000239456700003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1664]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Cai, YQ,Cai, GQ,Liu, GX,et al. Mice with genetically altered GABA transporter subtype 1 (GAT1) expression show altered behavioral responses to ethanol[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2006,84(2):255-267. |
| APA | Cai, YQ.,Cai, GQ.,Liu, GX.,Cai, Q.,Shi, JH.,...&Fei, J.(2006).Mice with genetically altered GABA transporter subtype 1 (GAT1) expression show altered behavioral responses to ethanol.JOURNAL OF NEUROSCIENCE RESEARCH,84(2),255-267. |
| MLA | Cai, YQ,et al."Mice with genetically altered GABA transporter subtype 1 (GAT1) expression show altered behavioral responses to ethanol".JOURNAL OF NEUROSCIENCE RESEARCH 84.2(2006):255-267. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。