Novel function of IFN-gamma: Negative regulation of dendritic cell migration and T cell priming
文献类型：期刊论文
| 作者 | Wu, XD; Hou, WQ; Sun, SH; Bi, EG; Wang, Y; Shi, MD; Zang, JW; Dong, C; Sun, B |
| 刊名 | JOURNAL OF IMMUNOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 177期号:2页码:934-943 |
| 通讯作者 | Sun, B (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Lab Mol Immunol, Lab Mol Cell Biol,Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,bsun@sibs.ac.cn |
| 英文摘要 | IFN-gamma is considered to be a Th1 cytokine with immunomodulatory effects on a variety of immune cells. In this study, we determined whether dendritic cell (DC) function was aberrant in IFN-gamma knockout (GKO) mice. The results demonstrated that IFN-gamma deficiency did not interfere with bone marrow-derived DC development and maturation in vitro. However, functional analysis showed that bone marrow-derived DC from GKO mice had altered cytokine secretion, allostimulatory and Ag presentation capacity, chemokine receptor expression, and in vitro chemotaxis. LPS induced the recruitment of DC from different organs into the spleen; epicutaneously sensitized DC with hapten (FITC) accumulated in the draining lymph nodes and CD11c(+) DC levels in the draining lymph nodes from autoantigen (interphotoreceptor retinoid-binding protein) immunized mice were enhanced in GKO mice as compared with wild-type mice. After treatment of GKO mice with i.p. IFN-gamma injection restored IFN-gamma levels in vivo, DC migration decreased in response to LPS or FITC. IFN-gamma altered the adaptive immune responses in vivo, since T cell priming and IL-2 production were increased in interphotoreceptor retinoid-binding protein-immunized GKO mice. Furthermore, in IFN-gamma-treated GKO mice, experimental autoimmune uveitis score enhancement and T cell activation were eliminated. Taken together, IFN-gamma appears to play a negative regulatory role on in vivo DC function, resulting in suppression of Ag-specific T cell priming. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | EXPERIMENTAL AUTOIMMUNE UVEITIS ; INTERFERON-GAMMA ; CROSS-PRESENTATION ; MICE ; ANTIGEN ; ACTIVATION ; MECHANISM ; LEADS ; ENCEPHALOMYELITIS ; INTERLEUKIN-12 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000238926500020 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1665]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wu, XD,Hou, WQ,Sun, SH,et al. Novel function of IFN-gamma: Negative regulation of dendritic cell migration and T cell priming[J]. JOURNAL OF IMMUNOLOGY,2006,177(2):934-943. |
| APA | Wu, XD.,Hou, WQ.,Sun, SH.,Bi, EG.,Wang, Y.,...&Sun, B.(2006).Novel function of IFN-gamma: Negative regulation of dendritic cell migration and T cell priming.JOURNAL OF IMMUNOLOGY,177(2),934-943. |
| MLA | Wu, XD,et al."Novel function of IFN-gamma: Negative regulation of dendritic cell migration and T cell priming".JOURNAL OF IMMUNOLOGY 177.2(2006):934-943. |
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