P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis
文献类型：期刊论文
| 作者 | Chen, M; Geng, JG |
| 刊名 | ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
 |
| 出版日期 | 2006 |
| 卷号 | 54期号:2页码:75-84 |
| 关键词 | selectin cell adhesion molecule leukocytes platelets endothelial cells cancer cells inflammation thrombosis cancer growth and metastasis |
| 通讯作者 | Geng, JG (reprint author), Univ Minnesota, Sch Med, Vasc Viol Ctr, MMC 480,420 Delaware St SE, Minneapolis, MN 55455 USA.,gengx011@umn.edu |
| 英文摘要 | Stimulated endothelial cells and activated platelets express P-selectin (CD62P), a member of the selectin family of cell adhesion molecules, which interacts with P-selectin glycoprotein ligand-1 (PSGL-1, CD162) for leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. Cross-linking of PSGL-1 by P-selectin also primes leukocytes intracellularly for cytokine and chemoattractant-induced beta(2)-integrin activation for firm adhesion of leukocytes. Furthermore, P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. Here we provide a comprehensive summary of the functional roles and the biological importance of P-selectin-mediated cell adhesive interactions in the pathogeneses of inflammation, thrombosis, and the growth and metastasis of cancers. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | ALPHA-GRANULE SECRETION ; VON-WILLEBRAND-FACTOR ; STIMULUS-INDUCED RELEASE ; HUMAN ENDOTHELIAL-CELLS ; GLYCOPROTEIN LIGAND-1 ; IN-VIVO ; CYTOPLASMIC DOMAIN ; MEMBRANE-PROTEIN ; NEUTROPHIL ADHESION ; DEFICIENT MICE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000237200700001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1668]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chen, M,Geng, JG. P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis[J]. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS,2006,54(2):75-84. |
| APA | Chen, M,&Geng, JG.(2006).P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis.ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS,54(2),75-84. |
| MLA | Chen, M,et al."P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis".ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 54.2(2006):75-84. |
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