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Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
文献类型：期刊论文
| 作者 | Wang, YY; Tang, YW; Teng, L; Wu, YL; Zhao, XH; Pei, G |
| 刊名 | NATURE IMMUNOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 7期号:2页码:139-147 |
| 通讯作者 | Pei, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Lab Mol Cell Biol, Shanghai 200031, Peoples R China.,gpei@sibs.ac.cn |
| 英文摘要 | Tumor necrosis factor receptor-associated factor 6 (TRAF6) is critical for mediating Toll-like receptor (TLR)-interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappa B and AP-1, transcriptional activators of innate immunity. Here we show that beta-arrestins, a family of multifunctional proteins, directly interacted with TRAF6 after TLR-IL-1R activation. Formation of the beta-arrestin- TRAF6 complex prevented autoubiquitination of TRAF6 and activation of NF-kappa B and AP-1. Endotoxin-treated beta-arrestin 2-deficient mice had higher expression of proinflammatory cytokines and were more susceptible to endotoxic shock. Thus, beta-arrestins are essential negative regulators of innate immune activation via TLR-IL-1R signaling. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | NF-KAPPA-B ; TRANSCRIPTION FACTORS ; BETA-ARRESTIN-2 ; ACTIVATION ; KINASE ; ENZYME ; UBIQUITINATION ; INTERLEUKIN-1 ; TRANSDUCTION ; RESPONSES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000234801700014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1674]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, YY,Tang, YW,Teng, L,et al. Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling[J]. NATURE IMMUNOLOGY,2006,7(2):139-147. |
| APA | Wang, YY,Tang, YW,Teng, L,Wu, YL,Zhao, XH,&Pei, G.(2006).Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.NATURE IMMUNOLOGY,7(2),139-147. |
| MLA | Wang, YY,et al."Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling".NATURE IMMUNOLOGY 7.2(2006):139-147. |
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