Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates
文献类型：期刊论文
| 作者 | Huang, CJ; Cheng, H; Hao, SF; Zhou, H; Zhang, XJ; Gao, JN; Sun, QH; Hu, HY; Wang, CC |
| 刊名 | JOURNAL OF MOLECULAR BIOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 364期号:3页码:323-336 |
| 关键词 | asynuclein fibril intermediate heat shock protein 70 chaperone |
| 通讯作者 | Wang, CC (reprint author), Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China.,chihwang@sun5.ibp.ac.cn |
| 英文摘要 | alpha-Synuclein (AS) is a main component of Lewy bodies in midbrain dopamine neurons pathologically characteristic of Parkinson's disease. We show that heat shock protein (Hsp) 70 inhibits AS fibril formation via preventing the formation of prefibrillar AS (PreAS), binding with PreAS to impede nuclei formation, and binding with nuclei to retard fibril elongation. Also, Hsp70 suppresses the PreAS-induced permeabilization of vesicular membrane through interactions with PreAS. The substrate-binding domain alone is sufficient for Hsp70 to inhibit AS fibril formation. The binding of Hsp70 with PreAS only requires the substrate-binding subdomain, and the binding with AS nuclei requires the C-terminal lid subdomain as well. The results may form the molecular basis for elucidating the mechanism of AS fibril formation and the crucial roles of chaperones in protecting proteins from toxic conversion in many conformational diseases. (c) 2006 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | PARKINSONS-DISEASE ; CHAPERONE ACTIVITY ; VESICLE PERMEABILIZATION ; MOLECULAR CHAPERONES ; SUBSTRATE-BINDING ; DROSOPHILA MODEL ; SENILE PLAQUES ; MECHANISM ; PROTEIN ; HSP70 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000242436200010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1679]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Huang, CJ,Cheng, H,Hao, SF,et al. Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates[J]. JOURNAL OF MOLECULAR BIOLOGY,2006,364(3):323-336. |
| APA | Huang, CJ.,Cheng, H.,Hao, SF.,Zhou, H.,Zhang, XJ.,...&Wang, CC.(2006).Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates.JOURNAL OF MOLECULAR BIOLOGY,364(3),323-336. |
| MLA | Huang, CJ,et al."Heat shock protein 70 inhibits alpha-synuclein fibril formation via interactions with diverse intermediates".JOURNAL OF MOLECULAR BIOLOGY 364.3(2006):323-336. |
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