Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism
文献类型：期刊论文
| 作者 | Lin, XJ; Zhang, F; Xie, YY; Bao, WJ; He, JH; Hu, HY |
| 刊名 | BIOPOLYMERS
 |
| 出版日期 | 2006 |
| 卷号 | 83期号:3页码:226-232 |
| 关键词 | alpha-synuclein circular dichroism g-factor aggregation GAV motif FTIR |
| 通讯作者 | Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Proteom, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,hyhu@sibs.ac.cn |
| 英文摘要 | alpha-Synuclein (alpha-Syn) has been identified as a component of intracellular fibrillar deposits in Parkinson's disease. Though the real pathogenesis is still unknown, many investigations have revealed that conformational alteration and fibril formation of alpha-Syn protein have an important role in causing the disease. In this work, we introduced the g-factor spectra of solid-state circular dichroism to estimate the secondary structure contents of alpha-Syn fragments in amyloids. Fourier-transform infrared (FTIR) was also applied to confirm the structural formation. The results suggest that the central hydrophobic region is critical for beta-sheet formation and the conformational alteration is the foundation of protein abnormal aggregation. The research provides a practical approach to estimate the secondary structure contents of protein amyloids and further insight into the relevance of structural transformation and amyloidogenesis. (c) 2006 Wiley Periodicals, Inc. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | BETA-SHEET ; NEURODEGENERATIVE DISEASE ; PROTEINS ; AGGREGATION ; FIBRILS ; FIBRILLIZATION ; COMPONENT ; REGION ; FILMS ; MOTIF |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000240709800003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1680]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Lin, XJ,Zhang, F,Xie, YY,et al. Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism[J]. BIOPOLYMERS,2006,83(3):226-232. |
| APA | Lin, XJ,Zhang, F,Xie, YY,Bao, WJ,He, JH,&Hu, HY.(2006).Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism.BIOPOLYMERS,83(3),226-232. |
| MLA | Lin, XJ,et al."Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism".BIOPOLYMERS 83.3(2006):226-232. |
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