Regulated expression of TAF1 in 1-cell mouse embryos
文献类型：期刊论文
| 作者 | Wang, K; Sun, F; Sheng, HZ |
| 刊名 | ZYGOTE
 |
| 出版日期 | 2006 |
| 卷号 | 14期号:3页码:209-215 |
| 关键词 | TBP TAF1 ZGA |
| 通讯作者 | Sheng, HZ (reprint author), Shanghai Jiao Tong Univ, Sch Med, Ctr Dev Biol, Xinhua Hosp, 1665 Kong Jiang Rd, Shanghai 200092, Peoples R China.,hzsheng2003@yahoo.com |
| 英文摘要 | TATA binding protein (TBP) associated factor 1 (TAF1) is a member of the general transcription machinery. Interference in the function of TAF1 causes a broad transcriptional defect in early development. To explore possible roles of TAF1 in embryonic transcriptional silence and zygotic genome activation, we examined the expression of TAF1 in 1-cell mouse embryos. Using an immunofluorescence assay, TAF1 was not detected in embryos in the first few hours after fertilization. TAF1 appeared in pronuclei 6 h post-fertilization and reached a relatively high level before zygotic genome activation. These data show that besides TBP, another critical member of the general transcription machinery such as TAF1 is also absent or at an extremely low level at the outset of development. Combined deficiency in critical members of the general transcription machinery may account for embryonic transcriptional silence. |
| 学科主题 | Cell Biology; Developmental Biology; Reproductive Biology |
| 类目[WOS] | Cell Biology ; Developmental Biology ; Reproductive Biology |
| 关键词[WOS] | BOX-BINDING PROTEIN ; MAJOR DEVELOPMENTAL TRANSITION ; EARLY XENOPUS-EMBRYOS ; GENE-EXPRESSION ; TRANSCRIPTIONAL ACTIVITY ; PREIMPLANTATION EMBRYO ; STAGE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000239106300004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1681]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, K,Sun, F,Sheng, HZ. Regulated expression of TAF1 in 1-cell mouse embryos[J]. ZYGOTE,2006,14(3):209-215. |
| APA | Wang, K,Sun, F,&Sheng, HZ.(2006).Regulated expression of TAF1 in 1-cell mouse embryos.ZYGOTE,14(3),209-215. |
| MLA | Wang, K,et al."Regulated expression of TAF1 in 1-cell mouse embryos".ZYGOTE 14.3(2006):209-215. |
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